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Tbio
BDP1
Transcription factor TFIIIB component B'' homolog

Protein Summary
Description
General activator of RNA polymerase III transcription. Requires for transcription from all three types of polymerase III promoters. Requires for transcription of genes with internal promoter elements and with promoter elements upstream of the initiation site. The product of this gene is a subunit of the TFIIIB transcription initiation complex, which recruits RNA polymerase III to target promoters in order to initiate transcription. The encoded protein localizes to concentrated aggregates in the nucleus, and is required for transcription from all three types of polymerase III promoters. It is phosphorylated by casein kinase II during mitosis, resulting in its release from chromatin and suppression of polymerase III transcription. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000358731
  • ENSP00000351575
  • ENSG00000145734
  • ENST00000617085
  • ENSP00000482469
  • ENSG00000273873

Symbol
  • KIAA1241
  • KIAA1689
  • TFNR
  • TFC5
  • TFNR
  • TAF3B1
  • DFNB112
  • TFIIIB''
  • TFIIIB90
  • HSA238520
  • TFIIIB150
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.72
cell type or tissue
0.68
cell line
0.66
histone modification site profile
0.64
transcription factor binding site profile
0.64


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 177.88   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 16   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 177.88   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 16   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (7)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
RNA Polymerase III Abortive And Retractive Initiation
Reactome
RNA Polymerase III Transcription
Reactome
RNA Polymerase III Transcription Initiation
Reactome
RNA Polymerase III Transcription Initiation From Type 1 Promoter
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
RNA Polymerase III Abortive And Retractive Initiation
RNA Polymerase III Transcription
RNA Polymerase III Transcription Initiation
RNA Polymerase III Transcription Initiation From Type 1 Promoter
Protein-Protein Interactions (115)
1 – 10 of 115
BRF2
Tbio
Novelty: 0.35928144
Score: 0.999
Data Source: Reactome,STRINGDB
BRF1
Tbio
Novelty: 0.00510161
Score: 0.997
Data Source: Reactome,STRINGDB
TBP
Tbio
Novelty: 0.00051191
Score: 0.996
Data Source: Reactome,STRINGDB
POLR3A
Tbio
Family: Enzyme
Novelty: 0.00525546
Score: 0.996
Data Source: STRINGDB
POLR3F
Tbio
Family: Enzyme
Novelty: 0.13846534
Score: 0.994
Data Source: STRINGDB
POLR3C
Tbio
Family: Enzyme
Novelty: 0.1416566
Score: 0.991
Data Source: STRINGDB
GTF3C1
Tbio
Novelty: 0.00651253
Score: 0.991
Data Source: STRINGDB
POLR1D
Tbio
Family: Enzyme
Novelty: 0.02859451
Score: 0.987
Data Source: STRINGDB
GTF3C3
Tdark
Novelty: 1.01962371
Score: 0.987
Data Source: STRINGDB
POLR3D
Tbio
Family: Enzyme
Novelty: 0.03502574
Score: 0.987
Data Source: STRINGDB
Publication Statistics
PubMed Score  177.88

PubMed score by year
PubTator Score  72.53

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer