Tbio BDP1 Transcription factor TFIIIB component B'' homolog

Protein Summary

Description

General activator of RNA polymerase III transcription. Requires for transcription from all three types of polymerase III promoters. Requires for transcription of genes with internal promoter elements and with promoter elements upstream of the initiation site. The product of this gene is a subunit of the TFIIIB transcription initiation complex, which recruits RNA polymerase III to target promoters in order to initiate transcription. The encoded protein localizes to concentrated aggregates in the nucleus, and is required for transcription from all three types of polymerase III promoters. It is phosphorylated by casein kinase II during mitosis, resulting in its release from chromatin and suppression of polymerase III transcription. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• A6H8Y1
• Q68DS6
• Q68DY5
• Q6MZL9
• Q6PIM7
• Q86W98
• Q96LR8
• Q9C0H4
• Q9H197
• Q9H1A1
• Q9HAW1
• Q9HAW2
• Q9HCY0
• Q9ULH9

Gene Name

• BDP1

Ensembl ID

• ENST00000358731
• ENSP00000351575
• ENSG00000145734
• ENST00000617085
• ENSP00000482469
• ENSG00000273873

Symbol

• KIAA1241
• KIAA1689
• TFNR
• TFC5
• TFNR
• TAF3B1
• DFNB112
• TFIIIB''
• TFIIIB90
• HSA238520
• TFIIIB150

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.72
cell type or tissue	0.68
cell line	0.66
histone modification site profile	0.64
transcription factor binding site profile	0.64

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Translation Factor / Translation Initiation Factor / Transcription Factor Tfiiib Component B'' Homolog

DTO Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Translation Factor / Translation Initiation Factor / Transcription Factor Tfiiib Component B'' Homolog

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 224.25   (req: < 5)

Gene RIFs: 8   (req: <= 3)

Antibodies: 16   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 224.25   (req: >= 5)

Gene RIFs: 8   (req: > 3)

Antibodies: 16   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0