Tdark MEGF11 Multiple epidermal growth factor-like domains protein 11

Protein Summary

Description

May regulate the mosaic spacing of specific neuron subtypes in the retina through homotypic retinal neuron repulsion. Mosaics provide a mechanism to distribute each cell type evenly across the retina, ensuring that all parts of the visual field have access to a full set of processing elements (By similarity).

Uniprot Accession IDs

• A6BM72
• Q17R86
• Q6UXS5
• Q8ND91
• Q96KG6
• Multiple EGF-like domains protein 11

Gene Name

• MEGF11

Ensembl ID

• ENST00000288745
• ENSP00000288745
• ENSG00000157890
• ENST00000409699
• ENSP00000386908
• ENST00000422354
• ENSP00000414475

Symbol

• KIAA1781

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
trait	0.97
histone modification site profile	0.69
cell type or tissue	0.68
transcription factor binding site profile	0.61
protein domain	0.58

Protein Classes

PANTHER Classes

Protein / Extracellular Matrix Protein / Multiple Epidermal Growth Factor-like Domains Protein 11

DTO Classes

Protein / Extracellular Structure / Multiple Epidermal Growth Factor-like Domains Protein 11

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.61   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 58   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.61   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 58   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0