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Tbio
CNOT1
CCR4-NOT transcription complex subunit 1

Protein Summary
Description
Scaffolding component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Its scaffolding function implies its interaction with the catalytic complex module and diverse RNA-binding proteins mediating the complex recruitment to selected mRNA 3'UTRs. Involved in degradation of AU-rich element (ARE)-containing mRNAs probably via association with ZFP36. Mediates the recruitment of the CCR4-NOT complex to miRNA targets and to the RISC complex via association with TNRC6A, TNRC6B or TNRC6C. Acts as a transcriptional repressor. Represses the ligand-dependent transcriptional activation by nuclear receptors. Involved in the maintenance of emryonic stem (ES) cell identity.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000317147
  • ENSP00000320949
  • ENSG00000125107
  • ENST00000441024
  • ENSP00000413113
  • ENST00000567188
  • ENSP00000456649
  • ENST00000569240
  • ENSP00000455635

Symbol
  • CDC39
  • KIAA1007
  • NOT1
  • NOT1
  • CDC39
  • NOT1H
  • AD-005
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
interacting protein
1
protein complex
1
biological process
0.94
molecular function
0.94


Related Tools
Target Illumination GWAS Analytics (TIGA)
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GENEVA
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 194.61   (req: < 5)
Gene RIFs: 19   (req: <= 3)
Antibodies: 72   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 194.61   (req: >= 5)
Gene RIFs: 19   (req: > 3)
Antibodies: 72   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
QT interval
4
5
0
2.3
96.6
3
4
0
1.1
56.4
pulse pressure measurement
1
1
1
48.1
apolipoprotein A 1 measurement
1
1
1
22.9
1
2
0
1.1
18.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
QT interval
0
2.3
96.6
0
1.1
56.4
pulse pressure measurement
1
48.1
apolipoprotein A 1 measurement
1
22.9
0
1.1
18.7
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
CCR4-NOT transcription complex subunit 1
VGNC:5742
454137
Macaque
CCR4-NOT transcription complex subunit 1
712880
Mouse
MGI:2442402
234594
Rat
RGD:1308009
291841
Dog
CCR4-NOT transcription complex subunit 1
VGNC:39410
608777
Species
Name
OMA
EggNOG
Inparanoid
Chimp
CCR4-NOT transcription complex subunit 1
Macaque
CCR4-NOT transcription complex subunit 1
Mouse
Rat
Dog
CCR4-NOT transcription complex subunit 1
Protein Structure (15 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-A5YKK6-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 15
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (16)
Deadenylation of mRNA (R-HSA-429947)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Deadenylation of mRNA
Reactome
Deadenylation-dependent mRNA decay
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
Metabolism of RNA
Name
Explore in Pharos
Explore in Source
Deadenylation of mRNA
Deadenylation-dependent mRNA decay
Gene expression (Transcription)
Generic Transcription Pathway
Metabolism of RNA
Gene Ontology Terms (27)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Protein-Protein Interactions (206)
1 – 10 of 206
NANOS2
Tbio
Novelty: 0.01489157
p_int: 0.999993092
p_ni: 0.000006908
Score: 0.952
Data Source: BioPlex,STRINGDB
CNOT3
Tbio
Novelty: 0.02463568
p_int: 0.999990534
p_ni: 0.000009467
Score: 0.999
Data Source: BioPlex,STRINGDB
CNOT11
Tbio
Novelty: 0.01687183
p_int: 0.99996606
p_ni: 0.00003394
Score: 0.999
Data Source: BioPlex,STRINGDB
TOB1
Tbio
Novelty: 0.0163328
p_int: 0.999892234
p_ni: 0.000107766
Score: 0.982
Data Source: BioPlex,STRINGDB
TEX13A
Tdark
Novelty: 1.13928013
p_int: 0.999885124
p_ni: 0.000114876
Score: 0.552
Data Source: BioPlex,STRINGDB
CNOT7
Tchem
Novelty: 0.04551853
p_int: 0.999851971
p_ni: 0.000148029
Score: 0.999
Data Source: BioPlex,STRINGDB
RIBC1
Tdark
Novelty: 0.40435429
p_int: 0.999820717
p_ni: 0.000179283
Score: 0.759
Data Source: BioPlex,STRINGDB
FANCD2OS
Tdark
Novelty: 9.51798561
p_int: 0.999683639
p_ni: 0.000316361
Data Source: BioPlex
CNOT10
Tdark
Novelty: 0.30195594
p_int: 0.998564921
p_ni: 0.001435079
Score: 0.996
Data Source: BioPlex,STRINGDB
GADD45B
Tbio
Novelty: 0.00611526
p_int: 0.997512871
p_ni: 0.002487129
Score: 0.787
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  194.61

PubMed score by year
PubTator Score  34.06

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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