HTR3E
5-hydroxytryptamine receptor 3E
Protein Summary
This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses. It is a cation-specific, but otherwise relatively nonselective, ion channel. This locus encodes a 5-hydroxytryptamine (serotonin) receptor subunit. The encoded protein, subunit E, may play a role in neurotransmission in myenteric neurons. Genes encoding subunits C, D and E form a cluster on chromosome 3. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Feb 2012]
- ENST00000335304
- ENSP00000335511
- ENSG00000186038
- ENST00000415389
- ENSP00000401444
- ENST00000425359
- ENSP00000401900
- ENST00000436361
- ENSP00000395833
- ENST00000440596
- ENSP00000406050
- 5-HT3E
- 5-HT3-E
- 5-HT3c1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
molecular function | 0.76 | ||
protein domain | 0.73 | ||
cell line | 0.63 | ||
phenotype | 0.58 | ||
disease | 0.43 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 12.55 (req: < 5)
Gene RIFs: 9 (req: <= 3)
Antibodies: 116 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 12.55 (req: >= 5)
Gene RIFs: 9 (req: > 3)
Antibodies: 116 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 7
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 2