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Tchem
HTR3E
5-hydroxytryptamine receptor 3E

Protein Summary
Description
This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses. It is a cation-specific, but otherwise relatively nonselective, ion channel. This locus encodes a 5-hydroxytryptamine (serotonin) receptor subunit. The encoded protein, subunit E, may play a role in neurotransmission in myenteric neurons. Genes encoding subunits C, D and E form a cluster on chromosome 3. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Feb 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000335304
  • ENSP00000335511
  • ENSG00000186038
  • ENST00000415389
  • ENSP00000401444
  • ENST00000425359
  • ENSP00000401900
  • ENST00000436361
  • ENSP00000395833
  • ENST00000440596
  • ENSP00000406050

Symbol
  • 5-HT3E
  • 5-HT3-E
  • 5-HT3c1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.76
protein domain
0.73
cell line
0.63
phenotype
0.58
disease
0.43


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.94   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 116   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.94   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 116   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (23)
1 – 10 of 23
ARL6IP5
Tbio
Novelty:  0.00871985
p_int:  0.997005786
p_ni:  0.002994214
Score:  0.187
Data Source:  BioPlex,STRINGDB
ATP2A3
Tchem
Family:  Transporter
Novelty:  0.0090982
p_int:  0.994902272
p_ni:  0.005097728
Score:  0.207
Data Source:  BioPlex,STRINGDB
AMFR
Tbio
Family:  Enzyme
Novelty:  0.00533547
p_int:  0.850492146
p_ni:  0.149507854
Score:  0.455
Data Source:  BioPlex,STRINGDB
HTR3A
Tclin
Family:  IC
Novelty:  0.00217443
Score:  0.939
Data Source:  Reactome,STRINGDB
HTR7
Tclin
Family:  GPCR
Novelty:  0.00169884
Score:  0.549
Data Source:  STRINGDB
ZNF491
Tdark
Family:  TF
Novelty:  4.75862069
Score:  0.529
Data Source:  STRINGDB
HTR5A
Tchem
Family:  GPCR
Novelty:  0.0160551
Score:  0.528
Data Source:  STRINGDB
SNCA
Tchem
Novelty:  0.00012042
Score:  0.501
Data Source:  STRINGDB
HTR1B
Tclin
Family:  GPCR
Novelty:  0.00073663
Score:  0.484
Data Source:  STRINGDB
HTR2A
Tclin
Family:  GPCR
Novelty:  0.00035566
Score:  0.48
Data Source:  STRINGDB
Pathways (5)
Neuronal System (R-HSA-112316)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Neuronal System
Reactome
Neurotransmitter receptors and postsynaptic signal transmission
Reactome
Transmission across Chemical Synapses
Name
Explore in Pharos
Explore in Source
Neuronal System
Neurotransmitter receptors and postsynaptic signal transmission
Transmission across Chemical Synapses
GWAS Traits (14)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
2
2
2
83.7
platelet count
1
1
1
81.1
myeloid white cell count
1
1
1
73.6
leukocyte count
1
1
1
70.8
platelet crit
1
1
1
69.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
2
83.7
platelet count
1
81.1
myeloid white cell count
1
73.6
leukocyte count
1
70.8
platelet crit
1
69.8
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Publication Statistics
PubMed Score 11.94
PubMed score by year
PubTator Score 8.67
PubTator score by year
Patents
Patents by year