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Tchem
PSD
PH and SEC7 domain-containing protein 1

Protein Summary
Description
Guanine nucleotide exchange factor for ARF6 (PubMed:23603394). Induces cytoskeletal remodeling (By similarity). This gene encodes a Plekstrin homology and SEC7 domains-containing protein that functions as a guanine nucleotide exchange factor. The encoded protein regulates signal transduction by activating ADP-ribosylation factor 6. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000020673
  • ENSP00000020673
  • ENSG00000059915
  • ENST00000406432
  • ENSP00000384830
  • ENST00000611678
  • ENSP00000481250

Symbol
  • EFA6
  • EFA6A
  • KIAA2011
  • PSD1
  • TYL
  • TYL
  • EFA6
  • PSD1
  • EFA6A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
0.87
disease perturbation
0.79
transcription factor
0.76
protein domain
0.73
virus perturbation
0.64


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 95.28   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 43   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 95.28   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 43   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 15
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (48)
ARF6
Tbio
Family:  Enzyme
Novelty:  0.00278138
Score:  0.992
Data Source:  STRINGDB
PISD
Tbio
Family:  Enzyme
Novelty:  0.00966227
Score:  0.787
Data Source:  STRINGDB
RAB11FIP5
Tbio
Novelty:  0.0264203
Score:  0.752
Data Source:  STRINGDB
RAB11FIP2
Tbio
Novelty:  0.06330621
Score:  0.716
Data Source:  STRINGDB
RAB11FIP1
Tbio
Novelty:  0.0445306
Score:  0.716
Data Source:  STRINGDB
KCNK1
Tbio
Family:  IC
Novelty:  0.01124588
Score:  0.691
Data Source:  STRINGDB
ARF1
Tchem
Family:  Enzyme
Novelty:  0.00208554
Score:  0.671
Data Source:  STRINGDB
PZP
Tbio
Novelty:  0.00670076
Score:  0.626
Data Source:  STRINGDB
CRLS1
Tbio
Family:  Enzyme
Novelty:  0.08214782
Score:  0.613
Data Source:  STRINGDB
SYT1
Tbio
Novelty:  0.00176103
Score:  0.61
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (25)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
2
0
1
81.4
intelligence
3
4
3
6.4
75.6
cognitive function measurement
2
1
2
65.6
platelet crit
1
1
1
64.4
1
1
0
1.1
63.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1
81.4
intelligence
3
6.4
75.6
cognitive function measurement
2
65.6
platelet crit
1
64.4
0
1.1
63.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
pleckstrin and Sec7 domain containing
VGNC:12440
746294
Macaque
pleckstrin and Sec7 domain containing
714737
Mouse
MGI:1920978
73728
Rat
RGD:620297
171381
Dog
pleckstrin and Sec7 domain containing
VGNC:45082
486859
Species
Name
OMA
EggNOG
Inparanoid
Chimp
pleckstrin and Sec7 domain containing
Macaque
pleckstrin and Sec7 domain containing
Mouse
Rat
Dog
pleckstrin and Sec7 domain containing
Publication Statistics
PubMed Score 95.28
PubMed score by year
PubTator Score 44.17
PubTator score by year
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Related Publications
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PMID
Year
Title