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Tbio
PSMB11
Proteasome subunit beta type-11

Protein Summary
Description
The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. Incorporated instead of PSMB5 or PSMB8, this unit reduces the chymotrypsin-like activity of the proteasome (By similarity). Plays a pivotal role in development of CD8-positive T cells (By similarity). Proteasomes generate peptides that are presented by major histocompatibility complex (MHC) I molecules to other cells of the immune system. Proteolysis is conducted by 20S proteasomes, complexes of 28 subunits arranged as a cylinder in 4 heteroheptameric rings: alpha-1 to -7, beta-1 to -7, beta-1 to -7, and alpha-1 to -7. The catalytic subunits are beta-1 (PSMB6; MIM 600307), beta-2 (PSMB7; MIM 604030), and beta-5 (PSMB5; MIM 600306). Three additional subunits, beta-1i (PSMB9; MIM 177045), beta-2i (PSMB10; MIM 176847), and beta- ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000408907
  • ENSP00000386212
  • ENSG00000222028

Symbol
  • BETA5T
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
pathway
1
biological process
0.96
cell type or tissue
0.92
protein domain
0.73
tissue sample
0.55


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.74   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 92   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.74   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 92   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
3
3
3
77.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
3
77.9
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1921152
73902
Rat
RGD:1308773
290206
Dog
proteasome subunit beta 11
VGNC:45094
100856222
Horse
proteasome subunit beta 11
VGNC:21940
100055985
Cow
proteasome subunit beta 11
VGNC:33445
538873
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
proteasome subunit beta 11
Horse
proteasome subunit beta 11
Cow
proteasome subunit beta 11
Pathways (138)
ABC transporter disorders (R-HSA-5619084)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 137
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ABC transporter disorders
Reactome
ABC-family proteins mediated transport
Reactome
APC/C-mediated degradation of cell cycle proteins
Reactome
APC/C:Cdc20 mediated degradation of Securin
Reactome
APC/C:Cdc20 mediated degradation of mitotic proteins
Name
Explore in Pharos
Explore in Source
ABC transporter disorders
ABC-family proteins mediated transport
APC/C-mediated degradation of cell cycle proteins
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdc20 mediated degradation of mitotic proteins
Protein-Protein Interactions (215)
1 – 10 of 215
PSMB2
Tclin
Family: Enzyme
Novelty: 0.06714761
Score: 0.994
Data Source: STRINGDB
PSMB1
Tclin
Family: Enzyme
Novelty: 0.0255917
Score: 0.994
Data Source: STRINGDB
PSMA1
Tclin
Family: Enzyme
Novelty: 0.013722
Score: 0.993
Data Source: STRINGDB
PSMA4
Tbio
Family: Enzyme
Novelty: 0.04515869
Score: 0.993
Data Source: STRINGDB
PSMB4
Tbio
Family: Enzyme
Novelty: 0.0376233
Score: 0.993
Data Source: STRINGDB
PSMA5
Tbio
Family: Enzyme
Novelty: 0.03862668
Score: 0.993
Data Source: STRINGDB
PSMB3
Tbio
Family: Enzyme
Novelty: 0.12791198
Score: 0.993
Data Source: STRINGDB
PSMA6
Tbio
Family: Enzyme
Novelty: 0.01525994
Score: 0.993
Data Source: STRINGDB
PSMA3
Tbio
Family: Enzyme
Novelty: 0.03106507
Score: 0.993
Data Source: STRINGDB
PSMD7
Tbio
Family: Enzyme
Novelty: 0.03090292
Score: 0.992
Data Source: STRINGDB
Publication Statistics
PubMed Score  24.74

PubMed score by year
PubTator Score  3.08

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer