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Tbio
VPS37C
Vacuolar protein sorting-associated protein 37C

Protein Summary
Description
Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation. VPS37C is a subunit of ESCRT-I (endosomal sorting complex required for transport I), a complex in the class E vacuolar protein sorting (VPS) pathway required for sorting ubiquitinated transmembrane proteins into internal vesicles of multivesicular bodies (Eastman et al., 2005 [PubMed 15509564]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000301765
  • ENSP00000301765
  • ENSG00000167987

Symbol
  • PML39
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.99
kinase perturbation
0.93
histone modification site profile
0.88
transcription factor binding site profile
0.8
virus perturbation
0.72


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.59   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 148   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.59   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 148   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
3
3
3
60.9
1
1
0
1.1
17.8
blood protein measurement
1
1
1
12.4
eosinophil percentage of leukocytes
1
1
1
11.5
1
1
0
1.1
9.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
3
60.9
0
1.1
17.8
blood protein measurement
1
12.4
eosinophil percentage of leukocytes
1
11.5
0
1.1
9.1
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
VPS37C, ESCRT-I subunit
VGNC:12774
451231
Macaque
VPS37C, ESCRT-I subunit
694898
Mouse
MGI:2147661
107305
Rat
RGD:1309258
308178
Dog
VPS37C, ESCRT-I subunit
VGNC:48288
483803
Species
Name
OMA
EggNOG
Inparanoid
Chimp
VPS37C, ESCRT-I subunit
Macaque
VPS37C, ESCRT-I subunit
Mouse
Rat
Dog
VPS37C, ESCRT-I subunit
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-A5D8V6-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (15)
Assembly Of The HIV Virion (R-HSA-175474)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 14
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Assembly Of The HIV Virion
Reactome
Autophagy
Reactome
Budding and maturation of HIV virion
Reactome
Disease
Reactome
Endosomal Sorting Complex Required For Transport (ESCRT)
Name
Explore in Pharos
Explore in Source
Assembly Of The HIV Virion
Autophagy
Budding and maturation of HIV virion
Disease
Endosomal Sorting Complex Required For Transport (ESCRT)
Gene Ontology Terms (12)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Protein-Protein Interactions (58)
1 – 10 of 58
SRSF2
Tbio
Novelty:  0.00207072
p_int:  0.920839093
p_ni:  0.07870889
p_wrong:  0.000452017
Data Source:  BioPlex
HOXB5
Tbio
Family:  TF
Novelty:  0.01119871
p_int:  0.8029241
p_ni:  0.197054515
p_wrong:  0.000021386
Score:  0.351
Data Source:  BioPlex,STRINGDB
VPS28
Tbio
Novelty:  0.02927315
Score:  0.996
Data Source:  Reactome,STRINGDB
TSG101
Tbio
Novelty:  0.00211746
Score:  0.991
Data Source:  Reactome,STRINGDB
MVB12A
Tbio
Novelty:  0.09794
Score:  0.981
Data Source:  Reactome,STRINGDB
MVB12B
Tbio
Novelty:  0.15964868
Score:  0.974
Data Source:  Reactome,STRINGDB
CHMP2A
Tbio
Novelty:  0.00169253
Score:  0.971
Data Source:  STRINGDB
VPS4A
Tbio
Novelty:  0.01508121
Score:  0.971
Data Source:  STRINGDB
CHMP4C
Tbio
Novelty:  0.07423155
Score:  0.967
Data Source:  STRINGDB
UBAP1
Tbio
Novelty:  0.02276845
Score:  0.965
Data Source:  Reactome,STRINGDB
Publication Statistics
PubMed Score  3.59

PubMed score by year
PubTator Score  3.25

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer