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Tbio
WDR91
WD repeat-containing protein 91

Protein Summary
Description
Functions as a negative regulator of the PI3 kinase/PI3K activity associated with endosomal membranes via BECN1, a core subunit of the PI3K complex. By modifying the phosphatidylinositol 3-phosphate/PtdInsP3 content of endosomal membranes may regulate endosome fusion, recycling, sorting and early to late endosome transport (PubMed:26783301). It is for instance, required for the delivery of cargos like BST2/tetherin from early to late endosome and thereby participates indirectly to their degradation by the lysosome (PubMed:27126989). May play a role in meiosis (By similarity).
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.74
cell line
0.57
tissue sample
0.56
small molecule perturbation
0.54
protein complex
0.5


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.34   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 79   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.34   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 79   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (42)
WFDC2
Tbio
Novelty:  0.0136923
p_int:  0.999864719
p_ni:  0.000135281
Score:  0.359
Data Source:  BioPlex,STRINGDB
CCT2
Tbio
Novelty:  0.01967139
p_int:  0.99006368
p_ni:  0.00993632
Data Source:  BioPlex
DNAL4
Tbio
Novelty:  0.15546154
p_int:  0.946862908
p_ni:  0.05313709
p_wrong:  2e-9
Data Source:  BioPlex
WDR81
Tbio
Novelty:  0.04564761
Score:  0.948
Data Source:  STRINGDB
PRRC2B
Tdark
Novelty:  0.28608235
Score:  0.764
Data Source:  STRINGDB
FAM180A
Tdark
Novelty:  2.46799861
Score:  0.743
Data Source:  STRINGDB
BECN1
Tbio
Novelty:  0.0003792
Score:  0.713
Data Source:  STRINGDB
ASB15
Tdark
Novelty:  0.11871549
Score:  0.713
Data Source:  STRINGDB
IQUB
Tdark
Novelty:  0.11732563
Score:  0.713
Data Source:  STRINGDB
VPS18
Tbio
Novelty:  0.00726539
Score:  0.652
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
aspartate aminotransferase measurement
1
1
0
7.5
59.9
serum alanine aminotransferase measurement
2
1
1
6.3
52.7
alkaline phosphatase measurement
1
1
1
31.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
aspartate aminotransferase measurement
0
7.5
59.9
serum alanine aminotransferase measurement
1
6.3
52.7
alkaline phosphatase measurement
1
31.3
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
WD repeat domain 91
VGNC:4563
463749
Macaque
WD repeat domain 91
707674
Mouse
MGI:2141558
101240
Rat
RGD:1306697
312225
Dog
WD repeat domain 91
VGNC:48398
482705
Species
Name
OMA
EggNOG
Inparanoid
Chimp
WD repeat domain 91
Macaque
WD repeat domain 91
Mouse
Rat
Dog
WD repeat domain 91
Publication Statistics
PubMed Score 9.34
PubMed score by year
PubTator Score 1.58
PubTator score by year
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Related Publications
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PMID
Year
Title