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Tbio
GTPBP10
GTP-binding protein 10

Protein Summary
Description
May be involved in the ribosome maturation process. Complements an ObgE(CgtA) function in E.coli ribosome maturation. Plays a role of GTPase in vitro. When missing, disorganization of the nucleolar architecture is observed. Small G proteins, such as GTPBP10, act as molecular switches that play crucial roles in the regulation of fundamental cellular processes such as protein synthesis, nuclear transport, membrane trafficking, and signal transduction (Hirano et al., 2006 [PubMed 17054726]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000222511
  • ENSP00000222511
  • ENSG00000105793
  • ENST00000257659
  • ENSP00000257659
  • ENST00000380058
  • ENSP00000369398

Symbol
  • OBGH2
  • ObgH2
  • UG0751c10
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.97
kinase perturbation
0.95
interacting protein
0.89
histone modification site profile
0.86
transcription factor binding site profile
0.78


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.33   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 147   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.33   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 147   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
homocysteine measurement
1
1
1
21.5
1
1
1
14.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
homocysteine measurement
1
21.5
1
14.2
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
GTP binding protein 10
VGNC:54162
463520
Macaque
GTP binding protein 10
704178
Mouse
MGI:2385599
207704
Rat
RGD:1305878
312054
Dog
GTP binding protein 10
VGNC:49806
100683980
Species
Name
OMA
EggNOG
Inparanoid
Chimp
GTP binding protein 10
Macaque
GTP binding protein 10
Mouse
Rat
Dog
GTP binding protein 10
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-A4D1E9-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (5)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (121)
1 – 10 of 121
BPNT1
Tbio
Family:  Enzyme
Novelty:  0.1114547
p_int:  0.999243175
p_ni:  0.000756748
p_wrong:  7.8e-8
Data Source:  BioPlex
MRPL30
Tdark
Novelty:  1.03623556
p_int:  0.999030231
p_ni:  0.000968633
p_wrong:  0.000001136
Data Source:  BioPlex
MRPS30
Tbio
Novelty:  0.08115544
p_int:  0.998213927
p_ni:  0.00178607
p_wrong:  3e-9
Score:  0.165
Data Source:  BioPlex,STRINGDB
MRPL50
Tdark
Novelty:  0.88879319
p_int:  0.99696532
p_ni:  0.003034647
p_wrong:  3.3e-8
Score:  0.228
Data Source:  BioPlex,STRINGDB
CLPB
Tbio
Family:  Enzyme
Novelty:  0.00209789
p_int:  0.994446785
p_ni:  0.005546535
p_wrong:  0.000006681
Score:  0.236
Data Source:  BioPlex,STRINGDB
PCBP4
Tbio
Novelty:  0.03763262
p_int:  0.99386973
p_ni:  0.006129603
p_wrong:  6.67e-7
Score:  0.513
Data Source:  BioPlex,STRINGDB
MECP2
Tchem
Family:  TF
Novelty:  0.00051767
p_int:  0.982082055
p_ni:  0.017640065
p_wrong:  0.000277879
Data Source:  BioPlex
FGF3
Tbio
Novelty:  0.00474087
p_int:  0.981463731
p_ni:  0.018062079
p_wrong:  0.00047419
Data Source:  BioPlex
SUCLA2
Tchem
Family:  Enzyme
Novelty:  0.02029861
p_int:  0.929224791
p_ni:  0.070711172
p_wrong:  0.000064037
Score:  0.219
Data Source:  BioPlex,STRINGDB
PLEKHO1
Tbio
Novelty:  0.01658553
p_int:  0.904141455
p_ni:  0.095830245
p_wrong:  0.0000283
Data Source:  BioPlex
Publication Statistics
PubMed Score  5.33

PubMed score by year
PubTator Score  1.84

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer