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Tbio
ISPD
D-ribitol-5-phosphate cytidylyltransferase

Protein Summary
Description
Cytidylyltransferase required for protein O-linked mannosylation (PubMed:22522420, PubMed:27130732, PubMed:27601598, PubMed:26687144, PubMed:22522421, PubMed:26923585). Catalyzes the formation of CDP-ribitol nucleotide sugar from D-ribitol 5-phosphate (PubMed:27130732, PubMed:26687144, PubMed:26923585). CDP-ribitol is a substrate of FKTN during the biosynthesis of the phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-3-N-acetylglucosamine-beta-4-(phosphate-6-)mannose), a carbohydrate structure present in alpha-dystroglycan (DAG1), which is required for binding laminin G-like domain-containing extracellular proteins with high affinity (PubMed:27130732, PubMed:26687144, PubMed:26923585). Shows activity toward other pentose phosphate sugars and mediates formation of CDP-ribulose or CDP-ribose using CTP and ribulose-5-phosphate or ribose-5-phosphate, respectively (PubMed:26687144). Not Involved in dolichol production (PubMed:26687144). This gene encodes a 2-C-methyl-D-ery ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000399310
  • ENSP00000382249
  • ENSG00000214960
  • ENST00000407010
  • ENSP00000385478

Symbol
  • Nip
  • ISPD
  • hISPD
  • MDDGA7
  • MDDGC7
  • LGMDR20
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.89
virus perturbation
0.64
disease
0.63
microRNA
0.57
phenotype
0.57


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 90.37   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 97   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 90.37   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 97   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
balding measurement
1
1
1
39.9
high density lipoprotein cholesterol measurement
1
1
1
16.2
Huntington disease
1
1
0
2.8
5.8
age at onset
1
1
0
2.8
5.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
balding measurement
1
39.9
high density lipoprotein cholesterol measurement
1
16.2
Huntington disease
0
2.8
5.8
age at onset
0
2.8
5.8
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (4)
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
KEGG
Mannose type O-glycan biosynthesis
KEGG
Metabolic pathways
KEGG
Pentose and glucuronate interconversions
Name
Explore in Pharos
Explore in Source
Mannose type O-glycan biosynthesis
Metabolic pathways
Pentose and glucuronate interconversions
Protein-Protein Interactions (81)
1 – 10 of 81
FKTN
Tbio
Novelty: 0.00981221
Score: 0.991
Data Source: STRINGDB
POMT2
Tbio
Family: Enzyme
Novelty: 0.0251595
Score: 0.917
Data Source: STRINGDB
POMT1
Tbio
Family: Enzyme
Novelty: 0.01971429
Score: 0.916
Data Source: STRINGDB
POMGNT1
Tbio
Family: Enzyme
Novelty: 0.00755927
Score: 0.897
Data Source: STRINGDB
RXYLT1
Tbio
Novelty: 0.14843707
Score: 0.877
Data Source: STRINGDB
POMGNT2
Tbio
Family: Enzyme
Novelty: 0.15109569
Score: 0.875
Data Source: STRINGDB
FKRP
Tbio
Novelty: 0.00798137
Score: 0.855
Data Source: STRINGDB
B3GALNT2
Tbio
Family: Enzyme
Novelty: 0.08266178
Score: 0.851
Data Source: STRINGDB
DOLK
Tbio
Family: Enzyme
Novelty: 0.00664639
Score: 0.84
Data Source: STRINGDB
GMPPB
Tbio
Family: Enzyme
Novelty: 0.05106206
Score: 0.824
Data Source: STRINGDB
Publication Statistics
PubMed Score  90.37

PubMed score by year
PubTator Score  74.94

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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