Tdark SSPO SCO-spondin

Protein Summary

Description

Involved in the modulation of neuronal aggregation. May be involved in developmental events during the formation of the central nervous system (By similarity).

Uniprot Accession IDs

• A2VEC9
• A0A096LNW2
• Q76B61

Gene Name

• SSPO

Ensembl ID

• ENST00000378016
• ENSP00000485256
• ENSG00000197558

Symbol

• KIAA2036

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	1
pathway	0.65
tissue sample	0.61
cell type or tissue	0.56
cell line	0.48

Protein Classes

PANTHER Classes

Protein / ... / Protease Inhibitor / Sco-spondin

DTO Classes

Protein / Enzyme Modulator / Protease Inhibitor / Sco-spondin

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 0   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 0   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (0)

No protein-protein interactions found

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (9)

Reactome (8)

PathwayCommons (1)

Defective B3GALTL causes Peters-plus syndrome (PpS) (R-HSA-5083635)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Defective B3GALTL causes Peters-plus syndrome (PpS)	38 targets	R-HSA-5083635
Reactome	Disease	1105 targets	R-HSA-1643685
Reactome	Diseases associated with O-glycosylation of proteins	71 targets	R-HSA-3906995
Reactome	Diseases of glycosylation	146 targets	R-HSA-3781865
Reactome	Metabolism of proteins	2050 targets	R-HSA-392499

Name	Explore in Pharos	Explore in Source
Defective B3GALTL causes Peters-plus syndrome (PpS)	38 targets	R-HSA-5083635
Disease	1105 targets	R-HSA-1643685
Diseases associated with O-glycosylation of proteins	71 targets	R-HSA-3906995
Diseases of glycosylation	146 targets	R-HSA-3781865
Metabolism of proteins	2050 targets	R-HSA-392499

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (5)

Functions (1)

Components (1)

Processes (3)

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10

1 – 1 of 1

GO Term	Evidence	Assigned by
peptidase inhibitor activity	Inferred from Electronic Annotation (IEA)	InterPro

Disease Associations ()

No disease associations found

GWAS Traits (7)

• Explore on Target Illumination GWAS Analytics (TIGA)

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1 – 5 of 7

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
mosaic loss of chromosome Y measurement	EFO_0007783	2	1	2		81.2
platelet crit	EFO_0007985	1	1	1		63.1
pulse pressure measurement	EFO_0005763	1	1	1		49.5
platelet count	EFO_0004309	1	1	1		31.4
systolic blood pressure change measurement	EFO_0006944	1	1	0	73.7	21.5

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 7

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
mosaic loss of chromosome Y measurement	EFO_0007783	2		81.2
platelet crit	EFO_0007985	1		63.1
pulse pressure measurement	EFO_0005763	1		49.5
platelet count	EFO_0004309	1		31.4
systolic blood pressure change measurement	EFO_0006944	0	73.7	21.5

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Alternative splicing
Calcium
Cell adhesion
Complete proteome
Disulfide bond
EGF-like domain
Glycoprotein
Polymorphism
Reference proteome
Repeat

GWAS Trait Find Similar Targets

No Header	No Header
C-reactive protein measurement
metabolite measurement
mosaic loss of chromosome Y measurement
platelet count
platelet crit
pulse pressure measurement
systolic blood pressure change measurement

IDG Resources

No IDG generated resources found

Orthologs (4)

1 – 4 of 4

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Mouse	SCO-spondin	MGI:2674311	243369
Rat	SCO-spondin	RGD:1549716	474348
Dog	SCO-spondin	VGNC:46836	482788
Zebrafish	subcommissural organ spondin	ZDB-GENE-051114-1	100036547

Species	Name	OMA	EggNOG	Inparanoid
Mouse	SCO-spondin
Rat	SCO-spondin
Dog	SCO-spondin
Zebrafish	subcommissural organ spondin

Publication Statistics

PubTator Score 6.56

PubTator score by year

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Related Publications

Text Mined References (14)

GeneRif Annotations (3)

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0 of 0

PMID	Year	Title