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Tbio
DENND3
DENN domain-containing protein 3

Protein Summary
Description
Guanine nucleotide exchange factor (GEF) activating RAB12. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB12 into its active GTP-bound form (PubMed:20937701). Regulates autophagy in response to starvation through RAB12 activation. Starvation leads to ULK1/2-dependent phosphorylation of Ser-472 and Ser-490, which in turn allows recruitment of 14-3-3 adapter proteins and leads to up-regulation of GEF activity towards RAB12 (By similarity). Also plays a role in protein transport from recycling endosomes to lysosomes, regulating, for instance, the degradation of the transferrin receptor and of the amino acid transporter PAT4 (PubMed:20937701). Starvation also induces phosphorylation at Tyr-858, which leads to up-regulated GEF activity and initiates autophagy (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262585
  • ENSP00000262585
  • ENSG00000105339
  • ENST00000424248
  • ENSP00000410594

Symbol
  • KIAA0870
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.94
protein domain
0.92
kinase perturbation
0.88
interacting protein
0.83
transcription factor binding site profile
0.76


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.42   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 32   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.42   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 32   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte measurement
3
2
3
57.4
leukocyte count
1
1
1
38.3
lymphocyte count
2
1
2
30.6
monocyte count
1
1
1
6.8
reticulocyte count
1
1
1
5.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte measurement
3
57.4
leukocyte count
1
38.3
lymphocyte count
2
30.6
monocyte count
1
6.8
reticulocyte count
1
5.9
Pathways (4)
Membrane Trafficking (R-HSA-199991)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Membrane Trafficking
Reactome
RAB GEFs exchange GTP for GDP on RABs
Reactome
Rab regulation of trafficking
Reactome
Vesicle-mediated transport
Name
Explore in Pharos
Explore in Source
Membrane Trafficking
RAB GEFs exchange GTP for GDP on RABs
Rab regulation of trafficking
Vesicle-mediated transport
Gene Ontology Terms (4)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Protein-Protein Interactions (41)
1 – 10 of 41
RAB12
Tbio
Family: Enzyme
Novelty: 0.05361391
Score: 0.968
Data Source: Reactome,STRINGDB
ULK1
Tchem
Family: Kinase
Novelty: 0.00240301
Score: 0.912
Data Source: Reactome,STRINGDB
CHML
Tbio
Family: Enzyme
Novelty: 0.00509709
Score: 0.9
Data Source: Reactome,STRINGDB
GDI1
Tbio
Novelty: 0.01710945
Score: 0.9
Data Source: Reactome,STRINGDB
CHM
Tbio
Family: Enzyme
Novelty: 0.00226278
Score: 0.9
Data Source: Reactome,STRINGDB
GDI2
Tbio
Novelty: 0.02861013
Score: 0.9
Data Source: Reactome,STRINGDB
NCLN
Tbio
Novelty: 0.10851333
Score: 0.594
Data Source: STRINGDB
RAB28
Tbio
Family: Enzyme
Novelty: 0.08899319
Score: 0.578
Data Source: STRINGDB
HEPHL1
Tbio
Novelty: 0.44678065
Score: 0.565
Data Source: STRINGDB
OR5J2
Tdark
Family: oGPCR
Novelty: 3.65419635
Score: 0.563
Data Source: STRINGDB
Publication Statistics
PubMed Score  5.42

PubMed score by year
PubTator Score  4.34

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer