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Tbio
CCDC66
Coiled-coil domain-containing protein 66

Protein Summary
Description
Microtubule-binding protein required for ciliogenesis (PubMed:28235840). May function in ciliogenesis by mediating the transport of proteins like BBS4 to the cilium, but also through the organization of the centriolar satellites (PubMed:28235840). Plays a role in retina morphogenesis and/or homeostasis (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000326595
  • ENSP00000326050
  • ENSG00000180376
  • ENST00000394672
  • ENSP00000378167
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cellular component
0.88
histone modification site profile
0.83
tissue sample
0.62
virus perturbation
0.55
transcription factor binding site profile
0.52


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.62   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 98   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.62   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 98   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
1
1
1
27
monocyte count
1
1
1
27
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
1
27
monocyte count
1
27
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
coiled-coil domain containing 66
VGNC:1761
460462
Macaque
coiled-coil domain containing 66
708564
Mouse
MGI:2443639
320234
Rat
RGD:1560873
306238
Dog
coiled-coil domain containing 66
VGNC:38850
476582
Species
Name
OMA
EggNOG
Inparanoid
Chimp
coiled-coil domain containing 66
Macaque
coiled-coil domain containing 66
Mouse
Rat
Dog
coiled-coil domain containing 66
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-A2RUB6-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (15)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Protein-Protein Interactions (48)
1 – 10 of 48
ANKRD36B
Tdark
Novelty: 2.44907149
p_int: 0.998710814
p_ni: 2.7e-8
p_wrong: 0.001289159
Data Source: BioPlex
CCDC18
Tdark
Novelty: 0.61246881
Score: 0.753
Data Source: STRINGDB
CEP290
Tbio
Novelty: 0.00526375
Score: 0.709
Data Source: STRINGDB
NXNL2
Tdark
Novelty: 0.46673216
Score: 0.701
Data Source: STRINGDB
CEP126
Tdark
Novelty: 0.25270575
Score: 0.682
Data Source: STRINGDB
CCDC13
Tbio
Novelty: 1.86380414
Score: 0.673
Data Source: STRINGDB
CFAP36
Tdark
Novelty: 0.42842118
Score: 0.641
Data Source: STRINGDB
PIBF1
Tbio
Novelty: 0.0454209
Score: 0.627
Data Source: STRINGDB
RD3
Tbio
Novelty: 0.00651981
Score: 0.618
Data Source: STRINGDB
PRICKLE3
Tbio
Novelty: 0.26347141
Score: 0.617
Data Source: STRINGDB
Publication Statistics
PubMed Score  12.62

PubMed score by year
PubTator Score  1.75

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer