You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
HMX2
Homeobox protein HMX2

Protein Summary
Description
Transcription factor involved in specification of neuronal cell types and which is required for inner ear and hypothalamus development. The protein encoded by this gene is a member of the NKL homeobox family of transcription factors. Members in this family are of ancient origin and play an important role in organ development during embryogenesis. A related mouse protein plays a role in patterning of inner ear structures. In humans, variations in a region containing this gene have been associated with inner ear malformations, vestibular dysfunction, and hearing loss. [provided by RefSeq, Aug 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000339992
  • ENSP00000341108
  • ENSG00000188816

Symbol
  • H6L
  • Nkx5-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
phenotype
0.67
PubMedID
0.63
biological process
0.6
cell type or tissue
0.6
protein domain
0.58


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.13   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 161   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.13   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 161   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:107159
15372
Rat
RGD:1565366
293538
Dog
H6 family homeobox 2
VGNC:41722
486925
Horse
H6 family homeobox 2
VGNC:18816
100057855
Cow
H6 family homeobox 2
VGNC:29888
525631
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
H6 family homeobox 2
Horse
H6 family homeobox 2
Cow
H6 family homeobox 2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-A2RU54-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Protein-Protein Interactions (22)
1 – 10 of 22
PPP1R21
Tdark
Family: Enzyme
Novelty: 0.33099657
Score: 0.711
Data Source: STRINGDB
HINFP
Tbio
Family: TF
Novelty: 0.09086304
Score: 0.711
Data Source: STRINGDB
LMO4
Tbio
Novelty: 0.08806373
Score: 0.61
Data Source: STRINGDB
HSPA12B
Tbio
Novelty: 0.06444663
Score: 0.59
Data Source: STRINGDB
ISY1
Tdark
Novelty: 1.68602768
Score: 0.556
Data Source: STRINGDB
DTNA
Tbio
Novelty: 0.01165754
Score: 0.556
Data Source: STRINGDB
DTNB
Tbio
Novelty: 0.0586565
Score: 0.556
Data Source: STRINGDB
HSD17B1
Tchem
Family: Enzyme
Novelty: 0.00313425
Score: 0.534
Data Source: STRINGDB
DHRS11
Tbio
Family: Enzyme
Novelty: 0.00352776
Score: 0.505
Data Source: STRINGDB
RARG
Tclin
Family: NR
Novelty: 0.00667159
Score: 0.504
Data Source: STRINGDB
Publication Statistics
PubMed Score  25.13

PubMed score by year
PubTator Score  13.76

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: