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Tdark
WDR27
WD repeat-containing protein 27

Protein Summary
Description
This gene encodes a protein with multiple WD repeats. Proteins with these repeats may form scaffolds for protein-protein interaction and play key roles in cell signalling. Alternative splicing results in multiple transcript variants, but the full-length structure of some of these variants cannot be determined. [provided by RefSeq, Nov 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000423258
  • ENSP00000397869
  • ENSG00000184465
  • ENST00000448612
  • ENSP00000416289
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.84
transcription factor binding site profile
0.77
tissue sample
0.7
transcription factor perturbation
0.61
cell line
0.6


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.75   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 95   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.75   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 95   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
1
1
1
72.4
smoking status measurement
1
1
1
50.2
neutrophil count
1
1
1
41.8
insomnia
1
1
0
5.6
36
insomnia measurement
1
1
0
1.1
32.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
1
72.4
smoking status measurement
1
50.2
neutrophil count
1
41.8
insomnia
0
5.6
36
insomnia measurement
0
1.1
32.7
Gene Ontology Terms (1)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
HPA
Protein-Protein Interactions (61)
1 – 10 of 61
HSPA8
Tchem
Novelty: 0.00081014
p_int: 0.803420923
p_ni: 0.196579077
Score: 0.267
Data Source: BioPlex,STRINGDB
PHF10
Tbio
Family: Epigenetic
Novelty: 0.05941323
Score: 0.825
Data Source: STRINGDB
BBS10
Tbio
Novelty: 0.03343798
Score: 0.791
Data Source: STRINGDB
TCTE3
Tdark
Novelty: 0.15747856
Score: 0.756
Data Source: STRINGDB
CXorf56
Tdark
Novelty: 0.39137617
Score: 0.718
Data Source: STRINGDB
C6orf120
Tdark
Novelty: 0.90888293
Score: 0.708
Data Source: STRINGDB
LRRC23
Tdark
Novelty: 0.67210911
Score: 0.69
Data Source: STRINGDB
PDXDC1
Tbio
Family: Enzyme
Novelty: 0.16529476
Score: 0.689
Data Source: STRINGDB
WRB
Tbio
Novelty: 0.01267171
Score: 0.672
Data Source: STRINGDB
FRMD1
Tdark
Novelty: 0.96833141
Score: 0.672
Data Source: STRINGDB
Publication Statistics
PubMed Score  0.75

PubMed score by year
PubTator Score  0.75

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer