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Tbio
HFM1
Probable ATP-dependent DNA helicase HFM1

Protein Summary
Description
Required for crossover formation and complete synapsis of homologous chromosomes during meiosis. The protein encoded by this gene is thought to be an ATP-dependent DNA helicase and is expressed mainly in germ-line cells. Defects in this gene are a cause of premature ovarian failure 9 (POF9). [provided by RefSeq, Apr 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000370425
  • ENSP00000359454
  • ENSG00000162669

Symbol
  • SEC3D1
  • MER3
  • POF9
  • Si-11
  • SEC63D1
  • Si-11-6
  • helicase
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.91
histone modification site profile
0.73
protein domain
0.73
cell line
0.52
tissue sample
0.46


Related Tools
GENEVA
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GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 60.91   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 106   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 60.91   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 106   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
HFM1, ATP dependent DNA helicase homolog
VGNC:11450
469233
Mouse
MGI:3036246
330149
Rat
RGD:1584010
690161
Dog
HFM1, ATP dependent DNA helicase homolog
VGNC:41672
479956
Horse
HFM1, ATP dependent DNA helicase homolog
VGNC:18767
100051719
Species
Name
OMA
EggNOG
Inparanoid
Chimp
HFM1, ATP dependent DNA helicase homolog
Mouse
Rat
Dog
HFM1, ATP dependent DNA helicase homolog
Horse
HFM1, ATP dependent DNA helicase homolog
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-A2PYH4-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (4)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (164)
1 – 10 of 164
MSH4
Tbio
Novelty: 0.00838156
Score: 0.943
Data Source: STRINGDB
MSH5
Tbio
Novelty: 0.0109825
Score: 0.922
Data Source: STRINGDB
SPO11
Tbio
Novelty: 0.00273994
Score: 0.869
Data Source: STRINGDB
MUS81
Tbio
Family: Enzyme
Novelty: 0.00532122
Score: 0.869
Data Source: STRINGDB
PRPF8
Tbio
Novelty: 0.01717158
Score: 0.852
Data Source: STRINGDB
MND1
Tbio
Novelty: 0.02206181
Score: 0.81
Data Source: STRINGDB
SLC2A4RG
Tbio
Family: Transporter
Novelty: 0.07239833
Score: 0.796
Data Source: STRINGDB
MLH3
Tbio
Novelty: 0.01295793
Score: 0.776
Data Source: STRINGDB
CCNB1IP1
Tbio
Family: Enzyme
Novelty: 0.0425612
Score: 0.76
Data Source: STRINGDB
MLH1
Tbio
Novelty: 0.00034212
Score: 0.755
Data Source: STRINGDB
Publication Statistics
PubMed Score  60.91

PubMed score by year
PubTator Score  687.22

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer