You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
A2ML1
Alpha-2-macroglobulin-like protein 1

Protein Summary
Description
Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase (By similarity). Displays inhibitory activity against chymotrypsin, papain, thermolysin, subtilisin A and, to a lesser extent, elastase but not trypsin. May play an important role during desquamation by inhibiting extracellular proteases. This gene encodes a member of the alpha-macroglobulin superfamily. The encoded protein is thought to be an N-glycosylated monomeric protein that ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000299698
  • ENSP00000299698
  • ENSG00000166535
  • ENST00000539547
  • ENSP00000438292

Symbol
  • CPAMD9
  • OMS
  • p170
  • CPAMD9
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.99
phenotype
0.75
cell line
0.59
cellular component
0.48
tissue
0.46


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.63   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 110   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.63   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 110   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (56)
TBC1D22B
Tbio
Novelty:  0.49852962
p_int:  0.99999713
p_ni:  0.000002868
p_wrong:  2e-9
Data Source:  BioPlex
TEFM
Tbio
Novelty:  0.10836617
p_int:  0.999996546
p_ni:  0.000003454
Data Source:  BioPlex
PDE4DIP
Tbio
Novelty:  0.03414104
p_int:  0.999992045
p_ni:  0.000007949
p_wrong:  6e-9
Data Source:  BioPlex
NPPA
Tchem
Novelty:  0.00046693
p_int:  0.99999149
p_ni:  0.000008196
p_wrong:  3.14e-7
Data Source:  BioPlex
FTH1
Tbio
Novelty:  0.000863
p_int:  0.99998081
p_ni:  0.00001919
Data Source:  BioPlex
L2HGDH
Tbio
Family:  Enzyme
Novelty:  0.01766669
p_int:  0.999926198
p_ni:  0.000073797
p_wrong:  6e-9
Score:  0.317
Data Source:  BioPlex,STRINGDB
KLHL11
Tbio
Novelty:  0.1537041
p_int:  0.999740593
p_ni:  0.000259407
Data Source:  BioPlex
FMNL2
Tbio
Novelty:  0.03453161
p_int:  0.999533017
p_ni:  0.000466946
p_wrong:  3.7e-8
Data Source:  BioPlex
FRMD1
Tdark
Novelty:  0.96833141
p_int:  0.999508133
p_ni:  0.000491867
Data Source:  BioPlex
PI4KA
Tchem
Family:  Kinase
Novelty:  0.01701469
p_int:  0.998692428
p_ni:  0.001307512
p_wrong:  6e-8
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (14)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
3
3
3
87.6
reticulocyte count
4
2
4
86.8
reticulocyte measurement
2
2
2
86.6
total cholesterol measurement
4
4
5
86
eosinophil count
2
2
2
79.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
3
87.6
reticulocyte count
4
86.8
reticulocyte measurement
2
86.6
total cholesterol measurement
5
86
eosinophil count
2
79.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
alpha-2-macroglobulin like 1
VGNC:8310
465375
Macaque
alpha-2-macroglobulin like 1
716616
Dog
alpha-2-macroglobulin like 1
VGNC:37400
486697
Horse
alpha-2-macroglobulin like 1
VGNC:14882
100061421
Cow
alpha-2-macroglobulin like 1
VGNC:25435
516769
Species
Name
OMA
EggNOG
Inparanoid
Chimp
alpha-2-macroglobulin like 1
Macaque
alpha-2-macroglobulin like 1
Dog
alpha-2-macroglobulin like 1
Horse
alpha-2-macroglobulin like 1
Cow
alpha-2-macroglobulin like 1
Publication Statistics
PubMed Score 22.63
PubMed score by year
PubTator Score 13.64
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title