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Tdark
PTPDC1
Protein tyrosine phosphatase domain-containing protein 1

Protein Summary
Description
May play roles in cilia formation and/or maintenance. The protein encoded by this gene contains a characteristic motif of protein tyrosine phosphatases (PTPs). PTPs regulate activities of phosphoproteins through dephosphorylation. They are signaling molecules involved in the regulation of a wide variety of biological processes. The specific function of this protein has not yet been determined. Alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000288976
  • ENSP00000288976
  • ENSG00000158079
  • ENST00000375360
  • ENSP00000364509
  • ENST00000650567
  • ENSP00000497158

Symbol
  • PTP9Q22
  • PTP9Q22
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.91
tissue sample
0.72
microRNA
0.67
transcription factor
0.61
transcription factor binding site profile
0.59


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.72   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 22   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.72   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 22   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
1
1
1
23
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
1
23
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
protein tyrosine phosphatase domain containing 1
VGNC:4838
465245
Macaque
protein tyrosine phosphatase domain containing 1
707878
Mouse
MGI:2145430
218232
Rat
RGD:1307698
291022
Dog
protein tyrosine phosphatase domain containing 1
VGNC:45165
476357
Species
Name
OMA
EggNOG
Inparanoid
Chimp
protein tyrosine phosphatase domain containing 1
Macaque
protein tyrosine phosphatase domain containing 1
Mouse
Rat
Dog
protein tyrosine phosphatase domain containing 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-A2A3K4-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Protein-Protein Interactions (58)
1 – 10 of 58
ARL2
Tbio
Family: Enzyme
Novelty: 0.01989908
p_int: 0.999866684
p_ni: 0.000132778
p_wrong: 5.38e-7
Score: 0.228
Data Source: BioPlex,STRINGDB
PPP2CA
Tchem
Family: Enzyme
Novelty: 0.00496839
p_int: 0.999783148
p_ni: 0.000216852
Score: 0.522
Data Source: BioPlex,STRINGDB
PPP2R2D
Tbio
Family: Enzyme
Novelty: 0.0658328
p_int: 0.999345246
p_ni: 0.000654754
Score: 0.696
Data Source: BioPlex,STRINGDB
CASK
Tchem
Family: Kinase
Novelty: 0.00856437
p_int: 0.995712707
p_ni: 0.004287277
p_wrong: 1.5e-8
Score: 0.236
Data Source: BioPlex,STRINGDB
PCBD1
Tbio
Family: Enzyme
Novelty: 0.01564376
p_int: 0.995604806
p_ni: 0.000036715
p_wrong: 0.004358479
Data Source: BioPlex
PPP2R1B
Tbio
Family: Enzyme
Novelty: 0.03936638
p_int: 0.994342603
p_ni: 0.005657397
Score: 0.599
Data Source: BioPlex,STRINGDB
PPP2R2A
Tchem
Family: Enzyme
Novelty: 0.01723628
p_int: 0.870908972
p_ni: 0.129091028
Score: 0.838
Data Source: BioPlex,STRINGDB
ENKUR
Tdark
Novelty: 0.35703467
Score: 0.626
Data Source: STRINGDB
IQUB
Tdark
Novelty: 0.11732563
Score: 0.586
Data Source: STRINGDB
RASL12
Tbio
Family: Enzyme
Novelty: 0.08794239
Score: 0.568
Data Source: STRINGDB
Publication Statistics
PubMed Score  1.72

PubMed score by year
PubTator Score  0.15

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer