Tchem MACROD2 O-acetyl-ADP-ribose deacetylase MACROD2

Protein Summary

Description

Removes ADP-ribose from glutamate residues in proteins bearing a single ADP-ribose moiety. Inactive towards proteins bearing poly-ADP-ribose. Deacetylates O-acetyl-ADP ribose, a signaling molecule generated by the deacetylation of acetylated lysine residues in histones and other proteins. The protein encoded by this gene is a deacetylase involved in removing ADP-ribose from mono-ADP-ribosylated proteins. The encoded protein has been shown to translocate from the nucleus to the cytoplasm upon DNA damage. [provided by RefSeq, May 2017]

Uniprot Accession IDs

• A1Z1Q3
• A6NFF7
• B0QZ39
• B3KWV0
• Q0P6D5
• Q495E0
• Q5W199
• Q6ZN71

Gene Name

• MACROD2

Ensembl ID

• ENST00000217246
• ENSP00000217246
• ENSG00000172264
• ENST00000378058
• ENSP00000367297
• ENST00000402914
• ENSP00000385290
• ENST00000407045
• ENSP00000385516

Symbol

• C20orf133
• C2orf133
• C20orf133

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
trait	1
transcription factor	0.75
phenotype	0.72
cell line	0.67
microRNA	0.66

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 48.91   (req: < 5)

Gene RIFs: 20   (req: <= 3)

Antibodies: 25   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 48.91   (req: >= 5)

Gene RIFs: 20   (req: > 3)

Antibodies: 25   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0