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Tbio
SSC5D
Soluble scavenger receptor cysteine-rich domain-containing protein SSC5D

Protein Classes
Protein Summary
Description
Binds to extracellular matrix proteins. Binds to pathogen-associated molecular patterns (PAMPs) present on the cell walls of Gram-positive and Gram-negative bacteria and fungi, behaving as a pattern recognition receptor (PRR). Induces bacterial and fungal aggregation and subsequent inhibition of PAMP-induced cytokine release. Does not possess intrinsic bactericidal activity. May play a role in the innate defense and homeostasis of certain epithelial surfaces (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000389623
  • ENSP00000374274
  • ENSG00000179954
  • ENST00000587166
  • ENSP00000467252

Symbol
  • S5D-SRCRB
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.54
cell line
0.5
tissue sample
0.49
gene perturbation
0.47
transcription factor
0.47


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.23   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 58   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.23   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 58   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
scavenger receptor cysteine rich family member with 5 domains
VGNC:10272
456305
Mouse
MGI:3606211
269855
Rat
RGD:1565772
308341
Dog
scavenger receptor cysteine rich family member with 5 domains
VGNC:53993
611280
Cow
scavenger receptor cysteine rich family member with 5 domains
VGNC:35310
530828
Species
Name
OMA
EggNOG
Inparanoid
Chimp
scavenger receptor cysteine rich family member with 5 domains
Mouse
Rat
Dog
scavenger receptor cysteine rich family member with 5 domains
Cow
scavenger receptor cysteine rich family member with 5 domains
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-A1L4H1-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (3)
Binding and Uptake of Ligands by Scavenger Receptors (R-HSA-2173782)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Binding and Uptake of Ligands by Scavenger Receptors
Reactome
Scavenging by Class B Receptors
Reactome
Vesicle-mediated transport
Name
Explore in Pharos
Explore in Source
Binding and Uptake of Ligands by Scavenger Receptors
Scavenging by Class B Receptors
Vesicle-mediated transport
Gene Ontology Terms (15)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Protein-Protein Interactions (10)
1 – 10 of 10
GCC2
Tbio
Novelty: 0.03809539
p_int: 0.999999553
p_ni: 4.47e-7
Score: 0.206
Data Source: BioPlex,STRINGDB
BIRC5
Tchem
Novelty: 0.00332112
p_int: 0.999725154
p_ni: 0.000248369
p_wrong: 0.000026477
Score: 0.187
Data Source: BioPlex,STRINGDB
RRAS
Tbio
Family: Enzyme
Novelty: 0.00786502
p_int: 0.907461829
p_ni: 0.061123072
p_wrong: 0.031415099
Score: 0.234
Data Source: BioPlex,STRINGDB
LDLRAD2
Tdark
Novelty: 1.67238137
Score: 0.572
Data Source: STRINGDB
FIBCD1
Tbio
Novelty: 0.1220783
Score: 0.479
Data Source: STRINGDB
DLEC1
Tbio
Novelty: 0.0300128
Score: 0.475
Data Source: STRINGDB
RIMKLA
Tdark
Family: Enzyme
Novelty: 0.30213465
Score: 0.473
Data Source: STRINGDB
LRRC10
Tdark
Novelty: 0.1402206
Score: 0.473
Data Source: STRINGDB
ST6GAL2
Tbio
Family: Enzyme
Novelty: 0.02408727
Score: 0.459
Data Source: STRINGDB
GPR162
Tbio
Family: GPCR
Novelty: 0.14938549
Score: 0.4
Data Source: STRINGDB
Publication Statistics
PubMed Score  5.23

PubMed score by year
PubTator Score  4.31

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer