You are using an outdated browser. Please upgrade your browser to improve your experience.

Tdark
PRSS38
Serine protease 38

Protein Summary
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000366757
  • ENSP00000355719
  • ENSG00000185888

Symbol
  • MPN2
  • MPN2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell line
0.61
protein domain
0.58
chemical
0.41
cell type or tissue
0.37
tissue
0.37


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.17   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 29   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.17   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 29   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist circumference
1
5
5
76.1
BMI-adjusted hip circumference
2
2
2
47.5
waist-hip ratio
1
1
1
30.2
BMI-adjusted waist-hip ratio
1
1
1
14.2
body height
1
1
1
13.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist circumference
5
76.1
BMI-adjusted hip circumference
2
47.5
waist-hip ratio
1
30.2
BMI-adjusted waist-hip ratio
1
14.2
body height
1
13.7
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
serine protease 38
VGNC:10347
469696
Mouse
MGI:2685095
216797
Rat
RGD:1565729
287358
Dog
serine protease 38
VGNC:45069
475179
Horse
serine protease 38
VGNC:21919
100061083
Species
Name
OMA
EggNOG
Inparanoid
Chimp
serine protease 38
Mouse
Rat
Dog
serine protease 38
Horse
serine protease 38
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-A1L453-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (2)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (8)
1 – 8 of 8
USB1
Tbio
Family:  Enzyme
Novelty:  0.01677996
Score:  0.669
Data Source:  STRINGDB
PPIAL4H
Tdark
Novelty:  1.19124381
Score:  0.646
Data Source:  STRINGDB
PPIAL4E
Tdark
Family:  Enzyme
Novelty:  1.19124381
Score:  0.646
Data Source:  STRINGDB
PPIAL4C
Tdark
Family:  Enzyme
Novelty:  1.19124381
Score:  0.646
Data Source:  STRINGDB
PPIAL4F
Tdark
Family:  Enzyme
Novelty:  1.07484372
Score:  0.607
Data Source:  STRINGDB
PPIAL4G
Tdark
Family:  Enzyme
Novelty:  0.93726521
Score:  0.551
Data Source:  STRINGDB
PPIAL4A
Tdark
Family:  Enzyme
Novelty:  0.76101999
Score:  0.515
Data Source:  STRINGDB
MDS2
Tdark
Novelty:  0.03492937
Score:  0.412
Data Source:  STRINGDB
Publication Statistics
PubMed Score  7.17

PubMed score by year
PubTator Score  3.25

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: