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Tdark
IGSF23
Immunoglobulin superfamily member 23

Protein Summary
Description
This gene encodes a protein that has one immunoglobulin (Ig) domain and is a member of the immunoglobulin superfamily. Proteins in this superfamily are usually found on or in cell membranes and act as receptors in immune response pathways. [provided by RefSeq, Nov 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000402988
  • ENSP00000385592
  • ENSG00000216588
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.85
cell line
0.46
tissue
0.44
gene perturbation
0.32
virus perturbation
0.32


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.64   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 8   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.64   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 8   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (20)
CEACAM19
Tbio
Novelty:  0.22803574
Score:  0.749
Data Source:  STRINGDB
REG4
Tbio
Novelty:  0.01123311
Score:  0.716
Data Source:  STRINGDB
EPS8L3
Tbio
Family:  Enzyme
Novelty:  0.15726999
Score:  0.633
Data Source:  STRINGDB
TM4SF20
Tbio
Novelty:  0.21582226
Score:  0.609
Data Source:  STRINGDB
CEACAM18
Tdark
Novelty:  0.57396129
Score:  0.607
Data Source:  STRINGDB
LCN15
Tdark
Novelty:  0.54935158
Score:  0.561
Data Source:  STRINGDB
GRIK5
Tclin
Family:  IC
Novelty:  0.00346213
Score:  0.553
Data Source:  STRINGDB
SLC6A19
Tchem
Family:  Transporter
Novelty:  0.01581031
Score:  0.535
Data Source:  STRINGDB
KRT77
Tbio
Novelty:  0.01331186
Score:  0.518
Data Source:  STRINGDB
SCGB2A2
Tbio
Novelty:  0.01594053
Score:  0.51
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (15)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
apolipoprotein B measurement
2
22
22
100
low density lipoprotein cholesterol measurement
4
17
18
99.9
total cholesterol measurement
2
11
11
99.9
C-reactive protein measurement
2
8
9
96.7
mean platelet volume
2
4
5
95.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
apolipoprotein B measurement
22
100
low density lipoprotein cholesterol measurement
18
99.9
total cholesterol measurement
11
99.9
C-reactive protein measurement
9
96.7
mean platelet volume
5
95.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
immunoglobulin superfamily member 23
456111
Macaque
immunoglobulin superfamily member 23
714249
Mouse
MGI:1917330
70080
Rat
RGD:1564357
502306
Dog
immunoglobulin superfamily member 23
VGNC:53726
612360
Species
Name
OMA
EggNOG
Inparanoid
Chimp
immunoglobulin superfamily member 23
Macaque
immunoglobulin superfamily member 23
Mouse
Rat
Dog
immunoglobulin superfamily member 23
Publication Statistics
PubMed Score 0.64
PubMed score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title