Tdark SYCE3 Synaptonemal complex central element protein 3

Protein Summary

Description

Major component of the transverse central element of synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase. Required for chromosome loading of the central element-specific SCS proteins, and for initiating synapsis between homologous chromosomes. Chromosome loading appears to require SYCP1. Required for fertility.

Uniprot Accession IDs

• A1L190

Gene Name

• SYCE3

Ensembl ID

• ENST00000402753
• ENSP00000385122
• ENSG00000217442
• ENST00000406915
• ENSP00000385480

Symbol

• C22orf41
• THEG2
• THEG2
• C22orf41

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.5
kinase perturbation	0.48
tissue	0.47
cellular component	0.46
phenotype	0.44

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.97   (req: < 5)

Gene RIFs: 1   (req: <= 3)

Antibodies: 6   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.97   (req: >= 5)

Gene RIFs: 1   (req: > 3)

Antibodies: 6   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0