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Tdark
FAM168B
Myelin-associated neurite-outgrowth inhibitor

Protein Summary
Description
Inhibitor of neuronal axonal outgrowth. Acts as a negative regulator of CDC42 and STAT3 and a positive regulator of STMN2. Positive regulator of CDC27.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000389915
  • ENSP00000374565
  • ENSG00000152102
  • ENST00000409185
  • ENSP00000387051

Symbol
  • KIAA0280L
  • MANI
  • MANI
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
1
histone modification site profile
0.89
cell type or tissue
0.81
microRNA
0.74
cellular component
0.71


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.91   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 49   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.91   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 49   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0