Tbio A1CF APOBEC1 complementation factor

Protein Summary

Description

Essential component of the apolipoprotein B mRNA editing enzyme complex which is responsible for the postranscriptional editing of a CAA codon for Gln to a UAA codon for stop in APOB mRNA. Binds to APOB mRNA and is probably responsible for docking the catalytic subunit, APOBEC1, to the mRNA to allow it to deaminate its target cytosine. The complex also protects the edited APOB mRNA from nonsense-mediated decay. Mammalian apolipoprotein B mRNA undergoes site-specific C to U deamination, which is mediated by a multi-component enzyme complex containing a minimal core composed of APOBEC-1 and a complementation factor encoded by this gene. The gene product has three non-identical RNA recognition motifs and belongs to the hnRNP R family of RNA-binding proteins. It has been proposed that this complementation factor functions as an RNA-binding subunit and docks APOBEC-1 to deaminate the upstream cytidine. Studies suggest that the protein may also be involved in other RNA editing or RNA processing events. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]

Uniprot Accession IDs

• Q9NQ94
• A1L4F2
• A8K7G7
• B7ZM14
• Q5SZQ0
• Q9NQ93
• Q9NQX8
• Q9NQX9
• Q9NXC9
• Q9NZD3

Gene Name

• A1CF

Ensembl ID

• ENST00000282641
• ENSP00000282641
• ENSG00000148584
• ENST00000373993
• ENSP00000363105
• ENST00000373995
• ENSP00000363107
• ENST00000373997
• ENSP00000363109
• ENST00000374001
• ENSP00000363113
• ENST00000395495
• ENSP00000378873

Symbol

• ACF
• ASP
• ACF
• ASP
• ACF64
• ACF65
• APOBEC1CF

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
microRNA	0.94
cell type or tissue	0.7
interacting protein	0.64
virus perturbation	0.59
protein domain	0.58

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.8   (req: < 5)

Gene RIFs: 10   (req: <= 3)

Antibodies: 182   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.8   (req: >= 5)

Gene RIFs: 10   (req: > 3)

Antibodies: 182   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0