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Tbio
SLC22A23
Solute carrier family 22 member 23

Protein Summary
Description
SLC22A23 belongs to a large family of transmembrane proteins that function as uniporters, symporters, and antiporters to transport organic ions across cell membranes (Jacobsson et al., 2007 [PubMed 17714910]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000380298
  • ENSP00000369653
  • ENSG00000137266
  • ENST00000380302
  • ENSP00000369657
  • ENST00000406686
  • ENSP00000385028
  • ENST00000490273
  • ENSP00000419463

Symbol
  • C6orf85
  • C6orf85
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.86
phenotype
0.78
tissue sample
0.76
PubMedID
0.71
transcription factor perturbation
0.68


Related Tools
RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.98   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 55   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.98   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 55   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intelligence
4
3
1
6
90.9
mean platelet volume
3
5
5
89.9
self reported educational attainment
2
2
1
6
87.7
red blood cell distribution width
3
6
6
82
2
2
0
1.1
49
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intelligence
1
6
90.9
mean platelet volume
5
89.9
self reported educational attainment
1
6
87.7
red blood cell distribution width
6
82
0
1.1
49
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 22 member 23
VGNC:11285
744613
Mouse
MGI:1920352
73102
Rat
RGD:620302
64559
Horse
solute carrier family 22 member 23
VGNC:23075
100058363
Pig
solute carrier family 22 member 23
100152838
Species
Name
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 22 member 23
Mouse
Rat
Horse
solute carrier family 22 member 23
Pig
solute carrier family 22 member 23
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-A1A5C7-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (3)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (43)
1 – 10 of 43
CLEC2D
Tbio
Novelty: 0.02501194
p_int: 0.999943606
p_ni: 0.000056394
p_wrong: 1e-9
Data Source: BioPlex
TNFRSF10C
Tbio
Novelty: 0.0088942
p_int: 0.999865161
p_ni: 0.000020483
p_wrong: 0.000114356
Data Source: BioPlex
ATP6V0D1
Tbio
Family: Enzyme
Novelty: 0.05146108
p_int: 0.999703064
p_ni: 0.000296936
Data Source: BioPlex
LGALS8
Tchem
Novelty: 0.00623836
p_int: 0.99969304
p_ni: 0.000306944
p_wrong: 1.5e-8
Data Source: BioPlex
BMP4
Tchem
Novelty: 0.00047387
p_int: 0.999521467
p_ni: 0.000458655
p_wrong: 0.000019878
Score: 0.188
Data Source: BioPlex,STRINGDB
LRRC55
Tbio
Family: IC
Novelty: 0.25121277
p_int: 0.99922526
p_ni: 0.00067839
p_wrong: 0.00009635
Data Source: BioPlex
DLK2
Tbio
Novelty: 0.06366405
p_int: 0.995442486
p_ni: 0.003627429
p_wrong: 0.000930085
Data Source: BioPlex
SIRT2
Tchem
Family: Epigenetic
Novelty: 0.00093962
p_int: 0.994113197
p_ni: 0.005870372
p_wrong: 0.000016431
Score: 0.183
Data Source: BioPlex,STRINGDB
PAXBP1
Tbio
Novelty: 0.13631396
p_int: 0.985932857
p_ni: 0.014067084
p_wrong: 5.9e-8
Score: 0.167
Data Source: BioPlex,STRINGDB
KPRP
Tdark
Novelty: 0.11744927
p_int: 0.979173145
p_ni: 0.0208079
p_wrong: 0.000018955
Score: 0.175
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  4.98

PubMed score by year
PubTator Score  4.84

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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