Tbio ANO9 Anoctamin-9

Protein Summary

Description

Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide (By similarity). Does not exhibit calcium-activated chloride channel (CaCC) activity. Can inhibit the activity of ANO1. The protein encoded by this gene is a member of the TMEM16 (anoctamin) family of proteins, some of which form integral membrane calcium-activated chloride channels. The function of the encoded protein has yet to be elucidated, although it may have channel-forming abilities and also may have phospholipid scramblase activity. This gene has been observed to be upregulated in stage II and III colorectal cancers. [provided by RefSeq, Dec 2016]

Uniprot Accession IDs

• A1A5B4
• B3KUC4
• B4E134
• Q8TEN4

Gene Name

• ANO9

Ensembl ID

• ENST00000332826
• ENSP00000332788
• ENSG00000185101

Symbol

• PIG5
• TMEM16J
• TP53I5
• PIG5
• TP53I5
• TMEM16J

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.78
molecular function	0.73
tissue sample	0.53
biological process	0.51
transcription factor	0.46

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.69   (req: < 5)

Gene RIFs: 6   (req: <= 3)

Antibodies: 64   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.69   (req: >= 5)

Gene RIFs: 6   (req: > 3)

Antibodies: 64   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Pathways (3)

Reactome (3)

Ion channel transport (R-HSA-983712)

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Items per page:

5

1 – 3 of 3

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Ion channel transport	179 targets	R-HSA-983712
Reactome	Stimuli-sensing channels	102 targets	R-HSA-2672351
Reactome	Transport of small molecules	725 targets	R-HSA-382551

Name	Explore in Pharos	Explore in Source
Ion channel transport	179 targets	R-HSA-983712
Stimuli-sensing channels	102 targets	R-HSA-2672351
Transport of small molecules	725 targets	R-HSA-382551

Gene Ontology Terms (10)

Functions (2)

Components (2)

Processes (6)

Items per page:

10

1 – 2 of 2

GO Term	Evidence	Assigned by
intracellular calcium activated chloride channel activity	Inferred from Mutant Phenotype (IMP)	UniProtKB
phospholipid scramblase activity	Inferred from Electronic Annotation (IEA)	Ensembl

Protein-Protein Interactions (22)

Explore Interacting Targets

1 – 10 of 22

• See Interactions on String-DB

PLSCR5

Tdark

Family: Enzyme

Novelty: 0.23764758

Score: 0.664

Data Source: STRINGDB

PLSCR2

Tdark

Family: Enzyme

Novelty: 0.17653318

Score: 0.638

Data Source: STRINGDB

TMEM80

Tdark

Novelty: 0.75

Score: 0.635

Data Source: STRINGDB

PLSCR4

Tbio

Family: Enzyme

Novelty: 0.10405081

Score: 0.592

Data Source: STRINGDB

LRRC8A

Tbio

Novelty: 0.01849951

Score: 0.551

Data Source: STRINGDB

RASSF7

Tbio

Novelty: 0.10160843

Score: 0.53

Data Source: STRINGDB

OSTC

Tbio

Family: Enzyme

Novelty: 0.10964149

Score: 0.529

Data Source: STRINGDB

FCAMR

Tbio

Novelty: 0.08272059

Score: 0.511

Data Source: STRINGDB

SIGIRR

Tbio

Novelty: 0.01894621

Score: 0.506

Data Source: STRINGDB

PLSCR1

Tbio

Family: Enzyme

Novelty: 0.01417587

Score: 0.504

Data Source: STRINGDB

Publication Statistics

PubMed Score  4.69

PubMed score by year

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PubTator Score  3.68

PubTator score by year

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Amino Acid Sequence

Residue Counts

Sequence

MQGEESLRILVEPEGDSFPLMEISTCETEASEQWDYVLVAQRHTQRDPRQARQQQFLEELRRKGFHIKVI

1-70

RDQKQVFFGIRADNSVFGLYRTLLLEPEGPAPHAELAAPTTIPVTTSLRIRIVNFVVMNNKTSAGETFED

70-140

LMKDGVFEARFPLHKGEGRLKKTWARWRHMFREQPVDEIRNYFGEKVALYFVWLGWYTYMLVPAALTGLL

140-210

VFLSGFSLFEASQISKEICEAHDILMCPLGDHSRRYQRLSETCTFAKLTHLFDNDGTVVFAIFMALWATV

210-280

FLEIWKRQRARVVLHWDLYVWDEEQEEMALQLINCPDYKLRPYQHSYLRSTVILVLTLLMICLMIGMAHV

280-350

LVVYRVLASALFSSSAVPFLEEQVTTAVVVTGALVHYVTIIIMTKINRCVALKLCDFEMPRTFSERESRF

350-420

TIRFFTLQFFTHFSSLIYIAFILGRINGHPGKSTRLAGLWKLEECHASGCMMDLFVQMAIIMGLKQTLSN

420-490

CVEYLVPWVTHKCRSLRASESGHLPRDPELRDWRRNYLLNPVNTFSLFDEFMEMMIQYGFTTIFVAAFPL

490-560

APLLALFSNLVEIRLDAIKMVWLQRRLVPRKAKDIGTWLQVLETIGVLAVIANGMVIAFTSEFIPRVVYK

560-630

YRYSPCLKEGNSTVDCLKGYVNHSLSVFHTKDFQDPDGIEGSENVTLCRYRDYRNPPDYNFSEQFWFLLA

630-700

IRLAFVILFEHVALCIKLIAAWFVPDIPQSVKNKVLEVKYQRLREKMWHGRQRLGGVGAGSRPPMPAHPT

700-770

PASIFSARSTDV

770-782

MQGEESLRILVEPEGDSFPLMEISTCETEASEQWDYVLVAQRHTQRDPRQARQQQFLEELRRKGFHIKVIRDQKQVFFGIRADNSVFGLYRTLLLEPEGPAPHAELAAPTTIPVTTSLRIRIVNFVVMNNKTSAGETFEDLMKDGVFEARFPLHKGEGRLKKTWARWRHMFREQPVDEIRNYFGEKVALYFVWLGWYTYMLVPAALTGLLVFLSGFSLFEASQISKEICEAHDILMCPLGDHSRRYQRLSETCTFAKLTHLFDNDGTVVFAIFMALWATVFLEIWKRQRARVVLHWDLYVWDEEQEEMALQLINCPDYKLRPYQHSYLRSTVILVLTLLMICLMIGMAHVLVVYRVLASALFSSSAVPFLEEQVTTAVVVTGALVHYVTIIIMTKINRCVALKLCDFEMPRTFSERESRFTIRFFTLQFFTHFSSLIYIAFILGRINGHPGKSTRLAGLWKLEECHASGCMMDLFVQMAIIMGLKQTLSNCVEYLVPWVTHKCRSLRASESGHLPRDPELRDWRRNYLLNPVNTFSLFDEFMEMMIQYGFTTIFVAAFPLAPLLALFSNLVEIRLDAIKMVWLQRRLVPRKAKDIGTWLQVLETIGVLAVIANGMVIAFTSEFIPRVVYKYRYSPCLKEGNSTVDCLKGYVNHSLSVFHTKDFQDPDGIEGSENVTLCRYRDYRNPPDYNFSEQFWFLLAIRLAFVILFEHVALCIKLIAAWFVPDIPQSVKNKVLEVKYQRLREKMWHGRQRLGGVGAGSRPPMPAHPTPASIFSARSTDV

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Uniprot Keyword

Alternative splicing
Cell membrane
Complete proteome
Glycoprotein
Lipid transport
Membrane
Polymorphism
Reference proteome
Transmembrane
Transmembrane helix