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Tbio
ANO9
Anoctamin-9

Protein Summary
Description
Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide (By similarity). Does not exhibit calcium-activated chloride channel (CaCC) activity. Can inhibit the activity of ANO1. The protein encoded by this gene is a member of the TMEM16 (anoctamin) family of proteins, some of which form integral membrane calcium-activated chloride channels. The function of the encoded protein has yet to be elucidated, although it may have channel-forming abilities and also may have phospholipid scramblase activity. This gene has been observed to be upregulated in stage II and III colorectal cancers. [provided by RefSeq, Dec 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000332826
  • ENSP00000332788
  • ENSG00000185101

Symbol
  • PIG5
  • TMEM16J
  • TP53I5
  • PIG5
  • TP53I5
  • TMEM16J
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.78
molecular function
0.73
tissue sample
0.53
biological process
0.51
transcription factor
0.46


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.38   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 64   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.38   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 64   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil percentage of leukocytes
2
2
2
92.4
eosinophil count
2
2
2
91.5
reticulocyte measurement
2
2
2
64.4
eosinophil percentage of granulocytes
1
1
1
58.4
neutrophil percentage of granulocytes
1
1
1
50.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil percentage of leukocytes
2
92.4
eosinophil count
2
91.5
reticulocyte measurement
2
64.4
eosinophil percentage of granulocytes
1
58.4
neutrophil percentage of granulocytes
1
50.6
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
anoctamin 9
VGNC:53048
100614913
Macaque
anoctamin 9
100425888
Mouse
MGI:1918595
71345
Rat
RGD:1560565
499287
Dog
anoctamin 9
VGNC:37931
483400
Species
Name
OMA
EggNOG
Inparanoid
Chimp
anoctamin 9
Macaque
anoctamin 9
Mouse
Rat
Dog
anoctamin 9
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-A1A5B4-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (3)
Ion channel transport (R-HSA-983712)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Ion channel transport
Reactome
Stimuli-sensing channels
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
Ion channel transport
Stimuli-sensing channels
Transport of small molecules
Protein-Protein Interactions (22)
1 – 10 of 22
PLSCR5
Tdark
Family:  Enzyme
Novelty:  1.58520094
Score:  0.664
Data Source:  STRINGDB
PLSCR2
Tdark
Family:  Enzyme
Novelty:  0.3663297
Score:  0.638
Data Source:  STRINGDB
TMEM80
Tdark
Novelty:  0.69499586
Score:  0.635
Data Source:  STRINGDB
PLSCR4
Tbio
Family:  Enzyme
Novelty:  0.12079798
Score:  0.592
Data Source:  STRINGDB
LRRC8A
Tbio
Novelty:  0.0163093
Score:  0.551
Data Source:  STRINGDB
RASSF7
Tbio
Novelty:  0.08011259
Score:  0.53
Data Source:  STRINGDB
OSTC
Tbio
Family:  Enzyme
Novelty:  0.06699106
Score:  0.529
Data Source:  STRINGDB
FCAMR
Tbio
Novelty:  0.05112165
Score:  0.511
Data Source:  STRINGDB
SIGIRR
Tbio
Novelty:  0.01438984
Score:  0.506
Data Source:  STRINGDB
PLSCR1
Tbio
Family:  Enzyme
Novelty:  0.01483138
Score:  0.504
Data Source:  STRINGDB
Publication Statistics
PubMed Score  7.38

PubMed score by year
PubTator Score  3.68

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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