Protein Summary
Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide (By similarity). Does not exhibit calcium-activated chloride channel (CaCC) activity. Can inhibit the activity of ANO1. The protein encoded by this gene is a member of the TMEM16 (anoctamin) family of proteins, some of which form integral membrane calcium-activated chloride channels. The function of the encoded protein has yet to be elucidated, although it may have channel-forming abilities and also may have phospholipid scramblase activity. This gene has been observed to be upregulated in stage II and III colorectal cancers. [provided by RefSeq, Dec 2016]
- ENST00000332826
- ENSP00000332788
- ENSG00000185101
- PIG5
- TMEM16J
- TP53I5
- PIG5
- TP53I5
- TMEM16J
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
gene perturbation | 0.78 | ||
molecular function | 0.73 | ||
tissue sample | 0.53 | ||
biological process | 0.51 | ||
transcription factor | 0.46 | ||
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 7.38 (req: < 5)
Gene RIFs: 6 (req: <= 3)
Antibodies: 64 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 7.38 (req: >= 5)
Gene RIFs: 6 (req: > 3)
Antibodies: 64 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 8
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
GWAS Traits (12)
Items per page:
1 – 5 of 12
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
eosinophil percentage of leukocytes | 2 | 2 | 2 | 92.4 | |||||
eosinophil count | 2 | 2 | 2 | 91.5 | |||||
reticulocyte measurement | 2 | 2 | 2 | 64.4 | |||||
eosinophil percentage of granulocytes | 1 | 1 | 1 | 58.4 | |||||
neutrophil percentage of granulocytes | 1 | 1 | 1 | 50.6 | |||||
Items per page:
1 – 5 of 12
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
eosinophil percentage of leukocytes | 2 | 92.4 | |||||
eosinophil count | 2 | 91.5 | |||||
reticulocyte measurement | 2 | 64.4 | |||||
eosinophil percentage of granulocytes | 1 | 58.4 | |||||
neutrophil percentage of granulocytes | 1 | 50.6 | |||||
Orthologs (9)
1 – 5 of 9
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | anoctamin 9 | VGNC:53048 | 100614913 | |||||
Macaque | anoctamin 9 | 100425888 | ||||||
Mouse | MGI:1918595 | 71345 | ||||||
Rat | RGD:1560565 | 499287 | ||||||
Dog | anoctamin 9 | VGNC:37931 | 483400 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | anoctamin 9 | |||||
Macaque | anoctamin 9 | |||||
Mouse | ||||||
Rat | ||||||
Dog | anoctamin 9 | |||||
Protein Structure (0 Structures, 1 AlphaFold Model)
Pathways (3)
Reactome (3)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 3 of 3
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Ion channel transport | ||||
Reactome | Stimuli-sensing channels | ||||
Reactome | Transport of small molecules | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Ion channel transport | ||||
Stimuli-sensing channels | ||||
Transport of small molecules | ||||
Gene Ontology Terms (10)
Functions (2)
Components (2)
Processes (6)
Items per page:
10
1 – 2 of 2
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Mutant Phenotype (IMP) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Protein-Protein Interactions (22)
1 – 10 of 22
PLSCR5
Family: Enzyme
Novelty: 1.58520094
Score: 0.664
Data Source: STRINGDB
PLSCR2
Family: Enzyme
Novelty: 0.3663297
Score: 0.638
Data Source: STRINGDB
TMEM80
Novelty: 0.69499586
Score: 0.635
Data Source: STRINGDB
PLSCR4
Family: Enzyme
Novelty: 0.12079798
Score: 0.592
Data Source: STRINGDB
LRRC8A
Novelty: 0.0163093
Score: 0.551
Data Source: STRINGDB
RASSF7
Novelty: 0.08011259
Score: 0.53
Data Source: STRINGDB
OSTC
Family: Enzyme
Novelty: 0.06699106
Score: 0.529
Data Source: STRINGDB
FCAMR
Novelty: 0.05112165
Score: 0.511
Data Source: STRINGDB
SIGIRR
Novelty: 0.01438984
Score: 0.506
Data Source: STRINGDB
PLSCR1
Family: Enzyme
Novelty: 0.01483138
Score: 0.504
Data Source: STRINGDB
Publication Statistics
PubMed Score 7.38
PubMed score by year
PubTator Score 3.68
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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