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Tbio
ARHGAP10
Rho GTPase-activating protein 10

Protein Summary
Description
GTPase activator for the small GTPases RhoA and Cdc42 by converting them to an inactive GDP-bound state. Essential for PTKB2 regulation of cytoskeletal organization via Rho family GTPases. Inhibits PAK2 proteolytic fragment PAK-2p34 kinase activity and changes its localization from the nucleus to the perinuclear region. Stabilizes PAK-2p34 thereby increasing stimulation of cell death (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000336498
  • ENSP00000336923
  • ENSG00000071205

Symbol
  • GRAF2
  • GRAF2
  • PSGAP
  • PS-GAP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
0.99
drug perturbation
0.87
histone modification site profile
0.79
kinase perturbation
0.76
transcription factor binding site profile
0.74


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.9   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 102   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.9   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 102   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alkaline phosphatase measurement
2
2
1
11.1
92.3
sex hormone-binding globulin measurement
6
2
6
91.2
central corneal thickness
2
2
0
3.5
81.6
hemoglobin measurement
2
2
2
80.6
hematocrit
2
2
2
78.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alkaline phosphatase measurement
1
11.1
92.3
sex hormone-binding globulin measurement
6
91.2
central corneal thickness
0
3.5
81.6
hemoglobin measurement
2
80.6
hematocrit
2
78.7
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
Rho GTPase activating protein 10
VGNC:699
471318
Macaque
Rho GTPase activating protein 10
708458
Mouse
MGI:1925764
78514
Rat
RGD:1588859
688429
Dog
Rho GTPase activating protein 10
VGNC:38045
482639
Species
Name
OMA
EggNOG
Inparanoid
Chimp
Rho GTPase activating protein 10
Macaque
Rho GTPase activating protein 10
Mouse
Rat
Dog
Rho GTPase activating protein 10
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-A1A4S6-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (13)
Apoptosis (R-HSA-109581)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Apoptosis
Reactome
Programmed Cell Death
Reactome
Regulation of Apoptosis
Reactome
Regulation of PAK-2p34 activity by PS-GAP/RHG10
Reactome
Rho GTPase cycle
Name
Explore in Pharos
Explore in Source
Apoptosis
Programmed Cell Death
Regulation of Apoptosis
Regulation of PAK-2p34 activity by PS-GAP/RHG10
Rho GTPase cycle
Gene Ontology Terms (8)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (42)
1 – 10 of 42
ARHGAP26
Tbio
Family:  Enzyme
Novelty:  0.02409941
p_int:  0.999999935
p_ni:  2e-9
p_wrong:  6.3e-8
Score:  0.836
Data Source:  BioPlex,STRINGDB
C2CD2
Tdark
Novelty:  0.34079266
p_int:  0.999999901
p_ni:  9.7e-8
p_wrong:  2e-9
Score:  0.912
Data Source:  BioPlex,STRINGDB
PKN3
Tchem
Family:  Kinase
Novelty:  0.0516816
Score:  0.985
Data Source:  STRINGDB
PAK2
Tchem
Family:  Kinase
Novelty:  0.0149123
Score:  0.975
Data Source:  Reactome,STRINGDB
CDC42
Tchem
Family:  Enzyme
Novelty:  0.00032619
Score:  0.974
Data Source:  STRINGDB
RHOA
Tbio
Family:  Enzyme
Novelty:  0.00022204
Score:  0.972
Data Source:  STRINGDB
ARF1
Tchem
Family:  Enzyme
Novelty:  0.00208554
Score:  0.921
Data Source:  STRINGDB
RAC1
Tbio
Family:  Enzyme
Novelty:  0.00365325
Score:  0.912
Data Source:  STRINGDB
RHOU
Tbio
Family:  Enzyme
Novelty:  0.01456329
Score:  0.908
Data Source:  STRINGDB
RHOC
Tbio
Family:  Enzyme
Novelty:  0.00262213
Score:  0.905
Data Source:  STRINGDB
Publication Statistics
PubMed Score  5.90

PubMed score by year
PubTator Score  11.18

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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