You are using an outdated browser. Please upgrade your browser to improve your experience.

Tdark
TMEM72
Transmembrane protein 72

Protein Summary
Description
This gene encodes a transmembrane protein which may be expressed specifically in the kidney. [provided by RefSeq, Sep 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000389583
  • ENSP00000374234
  • ENSG00000187783
  • ENST00000544540
  • ENSP00000439911

Symbol
  • C10orf127
  • KSP37
  • KSP37
  • C10orf127
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease
0.92
cell type or tissue
0.56
tissue
0.49
transcription factor
0.48
gene perturbation
0.47


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.02   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 19   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.02   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 19   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell density measurement
2
2
2
95.2
mean corpuscular volume
2
2
2
93.7
reticulocyte measurement
3
2
3
89.3
mean reticulocyte volume
1
1
1
84.3
erythrocyte count
1
1
1
82
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell density measurement
2
95.2
mean corpuscular volume
2
93.7
reticulocyte measurement
3
89.3
mean reticulocyte volume
1
84.3
erythrocyte count
1
82
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
transmembrane protein 72
VGNC:5823
746671
Mouse
MGI:2442707
319776
Rat
RGD:1308850
362424
Dog
transmembrane protein 72
VGNC:47603
100684938
Horse
transmembrane protein 72
VGNC:24313
100629248
Species
Name
OMA
EggNOG
Inparanoid
Chimp
transmembrane protein 72
Mouse
Rat
Dog
transmembrane protein 72
Horse
transmembrane protein 72
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-A0PK05-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (1)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (28)
1 – 10 of 28
LUZP2
Tdark
Novelty:  0.34485558
Score:  0.624
Data Source:  STRINGDB
SUSD2
Tbio
Novelty:  0.03954394
Score:  0.616
Data Source:  STRINGDB
TMEM100
Tbio
Novelty:  0.07486407
Score:  0.607
Data Source:  STRINGDB
SMIM34B
Tdark
Novelty:  65
Score:  0.589
Data Source:  STRINGDB
SMIM34A
Tdark
Novelty:  65
Score:  0.589
Data Source:  STRINGDB
STK32A
Tchem
Family:  Kinase
Novelty:  0.385805
Score:  0.578
Data Source:  STRINGDB
TMEM207
Tdark
Novelty:  0.35957705
Score:  0.573
Data Source:  STRINGDB
C22orf42
Tdark
Novelty:  3.51429983
Score:  0.571
Data Source:  STRINGDB
TMEM52B
Tdark
Novelty:  1.55824039
Score:  0.57
Data Source:  STRINGDB
TMPRSS5
Tbio
Family:  Enzyme
Novelty:  0.23903784
Score:  0.552
Data Source:  STRINGDB
Publication Statistics
PubMed Score  1.02

PubMed score by year
PubTator Score  2.62

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: