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Tdark
TMEM120B
Transmembrane protein 120B

Protein Summary
Description
Necessary for efficient adipogenesis.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000342607
  • ENSP00000345152
  • ENSG00000188735
  • ENST00000449592
  • ENSP00000404991
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.89
transcription factor
0.73
transcription factor binding site profile
0.73
small molecule perturbation
0.7
tissue sample
0.63


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.57   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 35   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.57   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 35   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
6
2
7
94.9
platelet crit
2
2
4
75
self reported educational attainment
1
1
1
69.5
myeloid white cell count
1
1
1
66.9
platelet count
2
1
2
66.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
7
94.9
platelet crit
4
75
self reported educational attainment
1
69.5
myeloid white cell count
1
66.9
platelet count
2
66.1
Gene Ontology Terms (4)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (51)
1 – 10 of 51
JTB
Tbio
Novelty: 0.06646216
p_int: 0.999849769
p_ni: 0.000150228
p_wrong: 3e-9
Data Source: BioPlex
MMP14
Tchem
Family: Enzyme
Novelty: 0.00083836
p_int: 0.999662208
p_ni: 0.000333009
p_wrong: 0.000004783
Data Source: BioPlex
YIPF3
Tbio
Novelty: 0.12021667
p_int: 0.999331354
p_ni: 0.000668643
p_wrong: 3e-9
Data Source: BioPlex
SLC39A4
Tbio
Family: Transporter
Novelty: 0.00742159
p_int: 0.999068301
p_ni: 0.000931409
p_wrong: 2.9e-7
Data Source: BioPlex
TNFSF18
Tbio
Novelty: 0.01423949
p_int: 0.998017776
p_ni: 0.001829044
p_wrong: 0.00015318
Data Source: BioPlex
ADGRE5
Tbio
Family: GPCR
Novelty: 0.01137558
p_int: 0.996863417
p_ni: 0.003086331
p_wrong: 0.000050251
Score: 0.216
Data Source: BioPlex,STRINGDB
LPAR1
Tchem
Family: GPCR
Novelty: 0.00318056
p_int: 0.996671145
p_ni: 0.003328846
p_wrong: 8e-9
Score: 0.159
Data Source: BioPlex,STRINGDB
CTLA4
Tclin
Novelty: 0.00012781
p_int: 0.996649384
p_ni: 0.003265272
p_wrong: 0.000085344
Data Source: BioPlex
SLC7A1
Tbio
Family: Transporter
Novelty: 0.00197313
p_int: 0.995227507
p_ni: 0.004609102
p_wrong: 0.000163391
Data Source: BioPlex
SLC7A14
Tbio
Family: Transporter
Novelty: 0.1613451
p_int: 0.990489519
p_ni: 0.009509448
p_wrong: 0.000001033
Data Source: BioPlex
Publication Statistics
PubMed Score  1.57

PubMed score by year
PubTator Score  0.78

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer