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Tbio
SLC5A10
Sodium/glucose cotransporter 5

Protein Summary
Description
High capacity transporter for mannose and fructose and, to a lesser extent, glucose, AMG, and galactose. This gene is a member of the sodium/glucose transporter family. Members of this family are sodium-dependent transporters and can be divided into two subfamilies based on sequence homology, one that co-transports sugars and the second that transports molecules such as ascorbate, choline, iodide, lipoate, monocaroboxylates, and pantothenate. The protein encoded by this gene has the highest affinity for mannose and has been reported to be most highly expressed in the kidney. This protein may function as a kidney-specific, sodium-dependent mannose and fructose co-transporter. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jul 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000317977
  • ENSP00000324346
  • ENSG00000154025
  • ENST00000395643
  • ENSP00000379005
  • ENST00000395645
  • ENSP00000379007
  • ENST00000395647
  • ENSP00000379008
  • ENST00000417251
  • ENSP00000401875

Symbol
  • SGLT5
  • SGLT5
  • SGLT-5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue sample
0.76
cell line
0.56
tissue
0.47
metabolite
0.45
phenotype
0.42


Related Tools
RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.43   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 84   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.43   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 84   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1,5 anhydroglucitol measurement
1
1
0
8.5
79.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1,5 anhydroglucitol measurement
0
8.5
79.8
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 5 member 10
VGNC:12676
101059023
Mouse
MGI:1926089
109342
Rat
RGD:1305232
303205
Dog
solute carrier family 5 member 10
VGNC:46443
102156040
Horse
solute carrier family 5 member 10
VGNC:23243
100051238
Species
Name
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 5 member 10
Mouse
Rat
Dog
solute carrier family 5 member 10
Horse
solute carrier family 5 member 10
Pathways (22)
Cellular hexose transport (R-HSA-189200)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cellular hexose transport
Reactome
SLC-mediated transmembrane transport
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
Cellular hexose transport
SLC-mediated transmembrane transport
Transport of small molecules
Gene Ontology Terms (5)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
Reactome
Protein-Protein Interactions (25)
1 – 10 of 25
FAM83G
Tbio
Novelty: 0.13274382
Score: 0.77
Data Source: STRINGDB
SLC9B2
Tbio
Family: Transporter
Novelty: 0.04898001
Score: 0.649
Data Source: STRINGDB
SLC2A2
Tchem
Family: Transporter
Novelty: 0.00103579
Score: 0.616
Data Source: STRINGDB
SLC2A10
Tbio
Family: Transporter
Novelty: 0.02548821
Score: 0.595
Data Source: STRINGDB
C16orf62
Tdark
Novelty: 0.33867321
Score: 0.583
Data Source: STRINGDB
LMF1
Tbio
Family: Enzyme
Novelty: 0.0280811
Score: 0.567
Data Source: STRINGDB
XK
Tbio
Novelty: 0.03770964
Score: 0.535
Data Source: STRINGDB
SLC35F5
Tdark
Family: Transporter
Novelty: 0.53360993
Score: 0.532
Data Source: STRINGDB
MARCH6
Tbio
Family: Enzyme
Novelty: 0.01818691
Score: 0.532
Data Source: STRINGDB
KCNV2
Tclin
Family: IC
Novelty: 0.02600406
Score: 0.522
Data Source: STRINGDB
Publication Statistics
PubMed Score  6.43

PubMed score by year
PubTator Score  6.39

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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