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Tbio
SHTN1
Shootin-1

Protein Summary
Description
Involved in the generation of internal asymmetric signals required for neuronal polarization and neurite outgrowth. Mediates netrin-1-induced F-actin-substrate coupling or 'clutch engagement' within the axon growth cone through activation of CDC42, RAC1 and PAK1-dependent signaling pathway, thereby converting the F-actin retrograde flow into traction forces, concomitantly with filopodium extension and axon outgrowth. Plays a role in cytoskeletal organization by regulating the subcellular localization of phosphoinositide 3-kinase (PI3K) activity at the axonal growth cone. Plays also a role in regenerative neurite outgrowth. In the developing cortex, cooperates with KIF20B to promote both the transition from the multipolar to the bipolar stage and the radial migration of cortical neurons from the ventricular zone toward the superficial layer of the neocortex. Involved in the accumulation of phosphatidylinositol 3,4,5-trisphosphate (PIP3) in the growth cone of primary hippocampal neurons.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000260777
  • ENSP00000260777
  • ENSG00000187164
  • ENST00000355371
  • ENSP00000347532
  • ENST00000392901
  • ENSP00000376635
  • ENST00000392903
  • ENSP00000376636
  • ENST00000615301
  • ENSP00000480109

Symbol
  • KIAA1598
  • KIAA1598
  • shootin-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.84   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 35   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.84   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 35   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cortical surface area measurement
1
2
0
15.9
96.1
6
3
1
1.3
88.8
body mass index
3
1
3
87
smoking status measurement
2
1
2
87
self reported educational attainment
2
2
2
83.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cortical surface area measurement
0
15.9
96.1
1
1.3
88.8
body mass index
3
87
smoking status measurement
2
87
self reported educational attainment
2
83.5
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
shootin 1
VGNC:5730
466211
Macaque
shootin 1
700636
Mouse
MGI:1918903
71653
Dog
shootin 1
VGNC:46160
486905
Horse
shootin 1
VGNC:22969
100067493
Species
Name
OMA
EggNOG
Inparanoid
Chimp
shootin 1
Macaque
shootin 1
Mouse
Dog
shootin 1
Horse
shootin 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-A0MZ66-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (4)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Developmental Biology
Reactome
L1CAM interactions
Reactome
Recycling pathway of L1
Name
Explore in Pharos
Explore in Source
Axon guidance
Developmental Biology
L1CAM interactions
Recycling pathway of L1
Gene Ontology Terms (27)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (40)
1 – 10 of 40
RNF41
Tbio
Family: Enzyme
Novelty: 0.01953473
p_int: 0.999999856
p_ni: 3.7e-8
p_wrong: 1.06e-7
Data Source: BioPlex
LURAP1L
Tdark
Novelty: 2.32630524
p_int: 0.999996307
p_ni: 0.000003689
p_wrong: 4e-9
Score: 0.516
Data Source: BioPlex,STRINGDB
FAM167A
Tbio
Novelty: 0.05232679
p_int: 0.999990142
p_ni: 0.000009858
Data Source: BioPlex
BCHE
Tclin
Family: Enzyme
Novelty: 0.00031267
p_int: 0.99976861
p_ni: 0.000231385
p_wrong: 4e-9
Score: 0.179
Data Source: BioPlex,STRINGDB
NDEL1
Tbio
Novelty: 0.01241819
p_int: 0.99881887
p_ni: 0.001177041
p_wrong: 0.000004089
Score: 0.214
Data Source: BioPlex,STRINGDB
TEX30
Tdark
Novelty: 0.69754742
p_int: 0.998519829
p_ni: 0.001480169
p_wrong: 3e-9
Data Source: BioPlex
ZCCHC17
Tbio
Novelty: 0.06999007
p_int: 0.998499935
p_ni: 0.001499219
p_wrong: 8.45e-7
Score: 0.184
Data Source: BioPlex,STRINGDB
FAM24B
Tdark
Novelty: 1.04675689
p_int: 0.926250056
p_ni: 0.068177957
p_wrong: 0.005571987
Data Source: BioPlex
CAV3
Tbio
Novelty: 0.00190092
p_int: 0.893475812
p_ni: 0.106185173
p_wrong: 0.000339015
Score: 0.185
Data Source: BioPlex,STRINGDB
L1CAM
Tbio
Novelty: 0.00307041
Score: 0.945
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  17.84

PubMed score by year
PubTator Score  8.95

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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