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Tbio
SHTN1
Shootin-1

Protein Summary
Description
Involved in the generation of internal asymmetric signals required for neuronal polarization and neurite outgrowth. Mediates netrin-1-induced F-actin-substrate coupling or 'clutch engagement' within the axon growth cone through activation of CDC42, RAC1 and PAK1-dependent signaling pathway, thereby converting the F-actin retrograde flow into traction forces, concomitantly with filopodium extension and axon outgrowth. Plays a role in cytoskeletal organization by regulating the subcellular localization of phosphoinositide 3-kinase (PI3K) activity at the axonal growth cone. Plays also a role in regenerative neurite outgrowth. In the developing cortex, cooperates with KIF20B to promote both the transition from the multipolar to the bipolar stage and the radial migration of cortical neurons from the ventricular zone toward the superficial layer of the neocortex. Involved in the accumulation of phosphatidylinositol 3,4,5-trisphosphate (PIP3) in the growth cone of primary hippocampal neurons.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000260777
  • ENSP00000260777
  • ENSG00000187164
  • ENST00000355371
  • ENSP00000347532
  • ENST00000392901
  • ENSP00000376635
  • ENST00000392903
  • ENSP00000376636
  • ENST00000615301
  • ENSP00000480109

Symbol
  • KIAA1598
  • KIAA1598
  • shootin-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.53   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 35   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.53   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 35   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (40)
RNF41
Tbio
Family:  Enzyme
Novelty:  0.01953473
p_int:  0.999999856
p_ni:  3.7e-8
p_wrong:  1.06e-7
Data Source:  BioPlex
LURAP1L
Tdark
Novelty:  2.32630524
p_int:  0.999996307
p_ni:  0.000003689
p_wrong:  4e-9
Score:  0.516
Data Source:  BioPlex,STRINGDB
FAM167A
Tbio
Novelty:  0.05232679
p_int:  0.999990142
p_ni:  0.000009858
Data Source:  BioPlex
BCHE
Tclin
Family:  Enzyme
Novelty:  0.00031267
p_int:  0.99976861
p_ni:  0.000231385
p_wrong:  4e-9
Score:  0.179
Data Source:  BioPlex,STRINGDB
NDEL1
Tbio
Novelty:  0.01241819
p_int:  0.99881887
p_ni:  0.001177041
p_wrong:  0.000004089
Score:  0.214
Data Source:  BioPlex,STRINGDB
TEX30
Tdark
Novelty:  0.69754742
p_int:  0.998519829
p_ni:  0.001480169
p_wrong:  3e-9
Data Source:  BioPlex
ZCCHC17
Tbio
Novelty:  0.06999007
p_int:  0.998499935
p_ni:  0.001499219
p_wrong:  8.45e-7
Score:  0.184
Data Source:  BioPlex,STRINGDB
FAM24B
Tdark
Novelty:  1.04675689
p_int:  0.926250056
p_ni:  0.068177957
p_wrong:  0.005571987
Data Source:  BioPlex
CAV3
Tbio
Novelty:  0.00190092
p_int:  0.893475812
p_ni:  0.106185173
p_wrong:  0.000339015
Score:  0.185
Data Source:  BioPlex,STRINGDB
L1CAM
Tbio
Novelty:  0.00307041
Score:  0.945
Data Source:  Reactome,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Developmental Biology
Reactome
L1CAM interactions
Reactome
Recycling pathway of L1
Name
Explore in Pharos
Explore in Source
Axon guidance
Developmental Biology
L1CAM interactions
Recycling pathway of L1
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (19)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cortical surface area measurement
1
2
0
15.9
80.3
7
4
1
1.3
74.3
Cleft palate
3
3
0
1.3
72.3
cup-to-disc ratio measurement
3
2
3
69.6
body mass index
3
1
3
63.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cortical surface area measurement
0
15.9
80.3
1
1.3
74.3
Cleft palate
0
1.3
72.3
cup-to-disc ratio measurement
3
69.6
body mass index
3
63.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
shootin 1
VGNC:5730
466211
Macaque
shootin 1
700636
Mouse
MGI:1918903
71653
Dog
shootin 1
VGNC:46160
486905
Horse
shootin 1
VGNC:22969
100067493
Species
Name
OMA
EggNOG
Inparanoid
Chimp
shootin 1
Macaque
shootin 1
Mouse
Dog
shootin 1
Horse
shootin 1
Publication Statistics
PubMed Score 18.53
PubMed score by year
PubTator Score 8.95
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title