Tbio ESYT2 Extended synaptotagmin-2

Protein Summary

Description

Tethers the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane. Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport. Plays a role in FGF signaling via its role in the rapid internalization of FGFR1 that has been activated by FGF1 binding; this occurs most likely via the AP-2 complex.

Uniprot Accession IDs

• A0FGR8
• A4D229
• Q69YJ2
• Q6UKI4
• Q6ZTU0
• Q6ZVU1
• Q9BQS0
• Q9NW47
• Q9ULJ2
• E-Syt2

Gene Name

• ESYT2

Ensembl ID

• ENST00000251527
• ENSP00000251527
• ENSG00000117868

Symbol

• FAM62B
• KIAA1228
• E-Syt2
• FAM62B
• CHR2SYT

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	0.99
kinase perturbation	0.99
transcription factor perturbation	0.97
transcription factor binding site profile	0.89
ligand (protein) perturbation	0.83

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 42.29   (req: < 5)

Gene RIFs: 4   (req: <= 3)

Antibodies: 93   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 42.29   (req: >= 5)

Gene RIFs: 4   (req: > 3)

Antibodies: 93   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0