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Tbio
ESYT2
Extended synaptotagmin-2

Protein Summary
Description
Tethers the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane. Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport. Plays a role in FGF signaling via its role in the rapid internalization of FGFR1 that has been activated by FGF1 binding; this occurs most likely via the AP-2 complex.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000251527
  • ENSP00000251527
  • ENSG00000117868

Symbol
  • FAM62B
  • KIAA1228
  • E-Syt2
  • FAM62B
  • CHR2SYT
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.99
kinase perturbation
0.99
transcription factor perturbation
0.97
transcription factor binding site profile
0.89
ligand (protein) perturbation
0.83


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.86   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 93   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.86   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 93   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (59)
ANKRD22
Tbio
Novelty:  0.28856283
p_int:  0.977992939
p_ni:  0.022007061
Data Source:  BioPlex
FURIN
Tchem
Family:  Enzyme
Novelty:  0.00055079
p_int:  0.898444473
p_ni:  0.101555527
Data Source:  BioPlex
TMEM9
Tbio
Novelty:  0.06916197
p_int:  0.898345298
p_ni:  0.101654702
Data Source:  BioPlex
ESYT1
Tbio
Novelty:  0.03069611
Score:  0.986
Data Source:  Reactome,STRINGDB
ESYT3
Tbio
Novelty:  0.08038584
Score:  0.941
Data Source:  Reactome,STRINGDB
DERL1
Tbio
Novelty:  0.01382722
Score:  0.861
Data Source:  STRINGDB
SYT14
Tbio
Novelty:  0.0413313
Score:  0.761
Data Source:  STRINGDB
WDR60
Tbio
Novelty:  0.13020561
Score:  0.69
Data Source:  STRINGDB
VWC2L
Tdark
Novelty:  1.5878556
Score:  0.686
Data Source:  STRINGDB
SYT16
Tbio
Novelty:  0.05270686
Score:  0.655
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Glycosphingolipid metabolism (R-HSA-1660662)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Glycosphingolipid metabolism
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Sphingolipid metabolism
Name
Explore in Pharos
Explore in Source
Glycosphingolipid metabolism
Metabolism
Metabolism of lipids
Sphingolipid metabolism
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (17)
Find Similar Targets
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
FlyBase
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Disease Associations ()
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
3
5
5
97.9
platelet count
1
1
1
68.8
platelet crit
1
1
1
47.7
influenza A (H1N1)
1
1
0
23.2
21.5
mosaic loss of chromosome Y measurement
1
1
1
6.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
5
97.9
platelet count
1
68.8
platelet crit
1
47.7
influenza A (H1N1)
0
23.2
21.5
mosaic loss of chromosome Y measurement
1
6.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
extended synaptotagmin 2
693942
Mouse
MGI:1261845
52635
Rat
RGD:1565705
299488
Dog
extended synaptotagmin 2
VGNC:40484
100683048
Horse
extended synaptotagmin 2
VGNC:17691
100057949
Species
Name
OMA
EggNOG
Inparanoid
Macaque
extended synaptotagmin 2
Mouse
Rat
Dog
extended synaptotagmin 2
Horse
extended synaptotagmin 2
Publication Statistics
PubMed Score 21.86
PubMed score by year
PubTator Score 6.03
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title