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Tchem
UBA6
Ubiquitin-like modifier-activating enzyme 6

Protein Classes
Protein Summary
Description
Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP. Specific for ubiquitin, does not activate ubiquitin-like peptides. Differs from UBE1 in its specificity for substrate E2 charging. Does not charge cell cycle E2s, such as CDC34. Essential for embryonic development. Required for UBD/FAT10 conjugation. Isoform 2 may play a key role in ubiquitin system and may influence spermatogenesis and male fertility. Modification of proteins with ubiquitin (UBB; MIM 191339) or ubiquitin-like proteins controls many signaling networks and requires a ubiquitin-activating enzyme (E1), a ubiquitin conjugating enzyme (E2), and a ubiquitin protein ligase (E3). UBE1L2 is an E1 enzyme that initiates the activation and conjugation of ubiquitin-like proteins (Jin et al., 2007 [PubMed 17597759]).[supplied by OMIM, Mar 2008]
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.99
histone modification site profile
0.88
molecular function
0.88
virus perturbation
0.85
transcription factor perturbation
0.8


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.67   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 243   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.67   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 243   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (1)
1 – 1 of 1
CHEMBL2017005
chemical structure image
Pathways (11)
Adaptive Immune System (R-HSA-1280218)

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Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
Immune System
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
Immune System
Metabolism of proteins
Protein-Protein Interactions (353)
1 – 10 of 353
UBE2L6
Tbio
Novelty: 0.05712698
p_int: 0.999919814
p_ni: 0.000080186
Score: 0.964
Data Source: BioPlex,STRINGDB
LINC01587
Tdark
Novelty: 0.58823529
p_int: 0.993808596
p_ni: 0.006191404
Data Source: BioPlex
SPANXN4
Tdark
Novelty: 8
p_int: 0.988770598
p_ni: 0.011229397
p_wrong: 5e-9
Data Source: BioPlex
ANKRD39
Tdark
p_int: 0.975219598
p_ni: 0.024773128
p_wrong: 0.000007273
Data Source: BioPlex
CAPN6
Tbio
Novelty: 0.02137262
p_int: 0.974302057
p_ni: 0.025694947
p_wrong: 0.000002996
Score: 0.169
Data Source: BioPlex,STRINGDB
PLEKHO1
Tbio
Novelty: 0.01414157
p_int: 0.964660167
p_ni: 0.035339362
p_wrong: 4.71e-7
Data Source: BioPlex
FYTTD1
Tbio
Novelty: 0.09345794
p_int: 0.95028948
p_ni: 0.049710142
p_wrong: 3.78e-7
Score: 0.162
Data Source: BioPlex,STRINGDB
ALDH3B1
Tbio
Family: Enzyme
Novelty: 0.05626574
p_int: 0.936657745
p_ni: 0.063341859
p_wrong: 3.96e-7
Score: 0.198
Data Source: BioPlex,STRINGDB
OR5F1
Tdark
Family: oGPCR
p_int: 0.936211011
p_ni: 0.06378791
p_wrong: 0.000001079
Score: 0.234
Data Source: BioPlex,STRINGDB
RAB2B
Tdark
Family: Enzyme
Novelty: 0.27592248
p_int: 0.926517724
p_ni: 0.072093271
p_wrong: 0.001389005
Score: 0.205
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  8.67

PubMed score by year
PubTator Score  11.01

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
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