Tchem UBA6 Ubiquitin-like modifier-activating enzyme 6

Protein Summary

Description

Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP. Specific for ubiquitin, does not activate ubiquitin-like peptides. Differs from UBE1 in its specificity for substrate E2 charging. Does not charge cell cycle E2s, such as CDC34. Essential for embryonic development. Required for UBD/FAT10 conjugation. Isoform 2 may play a key role in ubiquitin system and may influence spermatogenesis and male fertility. Modification of proteins with ubiquitin (UBB; MIM 191339) or ubiquitin-like proteins controls many signaling networks and requires a ubiquitin-activating enzyme (E1), a ubiquitin conjugating enzyme (E2), and a ubiquitin protein ligase (E3). UBE1L2 is an E1 enzyme that initiates the activation and conjugation of ubiquitin-like proteins (Jin et al., 2007 [PubMed 17597759]).[supplied by OMIM, Mar 2008]

Uniprot Accession IDs

• A0AVT1
• A6N8M7
• B2RAV3
• Q4W5K0
• Q6UV21
• Q86T78
• Q86TC7
• Q8N5T3
• Q8N9E4
• Q9H3T7
• Q9NVC9
• Ubiquitin-activating enzyme 6

Gene Name

• UBA6

Ensembl ID

• ENST00000322244
• ENSP00000313454
• ENSG00000033178
• ENST00000420827
• ENSP00000399234

Symbol

• MOP4
• UBE1L2
• E1-L2
• MOP-4
• UBE1L2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.99
histone modification site profile	0.88
molecular function	0.88
virus perturbation	0.85
transcription factor perturbation	0.8

Protein Classes

PANTHER Classes

Protein / Transfer/carrier Protein / Ubiquitin-like Modifier-activating Enzyme 6

Protein / Ligase / Ubiquitin-like Modifier-activating Enzyme 6

DTO Classes

Protein / Enzyme / Ligase / Ubiquitin-like Modifier-activating Enzyme 6

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.41   (req: < 5)

Gene RIFs: 14   (req: <= 3)

Antibodies: 243   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.41   (req: >= 5)

Gene RIFs: 14   (req: > 3)

Antibodies: 243   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0