Tbio E2F8 Transcription factor E2F8

Protein Summary

Description

Atypical E2F transcription factor that participates in various processes such as angiogenesis and polyploidization of specialized cells. Mainly acts as a transcription repressor that binds DNA independently of DP proteins and specifically recognizes the E2 recognition site 5'-TTTC[CG]CGC-3'. Directly represses transcription of classical E2F transcription factors such as E2F1: component of a feedback loop in S phase by repressing the expression of E2F1, thereby preventing p53/TP53-dependent apoptosis. Plays a key role in polyploidization of cells in placenta and liver by regulating the endocycle, probably by repressing genes promoting cytokinesis and antagonizing action of classical E2F proteins (E2F1, E2F2 and/or E2F3). Required for placental development by promoting polyploidization of trophoblast giant cells. Acts as a promoter of sprouting angiogenesis, possibly by acting as a transcription activator: associates with HIF1A, recognizes and binds the VEGFA promoter, which is different from canonical E2 recognition site, and activates expression of the VEGFA gene. This gene encodes a member of a family of transcription factors which regulate the expression of genes required for progression through the cell cycle. The encoded protein regulates progression from G1 to S phase by ensuring the nucleus divides at the proper time. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jan 2012]

Uniprot Accession IDs

• A0AVK6
• A8K9H3
• Q2VPJ3
• Q3C1U6
• Q5BKY4
• Q8N340
• Q9H5M0
• E2F-8

Gene Name

• E2F8

Ensembl ID

• ENST00000250024
• ENSP00000250024
• ENSG00000129173
• ENST00000527884
• ENSP00000434199
• ENST00000620009
• ENSP00000481103

Symbol

• E2F-8

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.95
molecular function	0.94
biological process	0.83
histone modification site profile	0.68
transcription factor perturbation	0.68

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Transcription Factor E2f8

Protein / Nucleic Acid Binding / Transcription Factor E2f8

DTO Classes

Protein / Nucleic Acid Binding / Transcription Factor E2f8

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 99.62   (req: < 5)

Gene RIFs: 26   (req: <= 3)

Antibodies: 183   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 99.62   (req: >= 5)

Gene RIFs: 26   (req: > 3)

Antibodies: 183   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 23

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0