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Tbio
E2F8
Transcription factor E2F8

Protein Summary
Description
Atypical E2F transcription factor that participates in various processes such as angiogenesis and polyploidization of specialized cells. Mainly acts as a transcription repressor that binds DNA independently of DP proteins and specifically recognizes the E2 recognition site 5'-TTTC[CG]CGC-3'. Directly represses transcription of classical E2F transcription factors such as E2F1: component of a feedback loop in S phase by repressing the expression of E2F1, thereby preventing p53/TP53-dependent apoptosis. Plays a key role in polyploidization of cells in placenta and liver by regulating the endocycle, probably by repressing genes promoting cytokinesis and antagonizing action of classical E2F proteins (E2F1, E2F2 and/or E2F3). Required for placental development by promoting polyploidization of trophoblast giant cells. Acts as a promoter of sprouting angiogenesis, possibly by acting as a transcription activator: associates with HIF1A, recognizes and binds the VEGFA promoter, which is different ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000250024
  • ENSP00000250024
  • ENSG00000129173
  • ENST00000527884
  • ENSP00000434199
  • ENST00000620009
  • ENSP00000481103

Symbol
  • E2F-8
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.95
molecular function
0.94
biological process
0.83
histone modification site profile
0.68
transcription factor perturbation
0.68


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 86.88   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 183   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 86.88   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 183   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 23
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
2
4
4
91.9
mean reticulocyte volume
1
3
3
90.8
mean corpuscular hemoglobin concentration
1
1
1
85.2
red blood cell density measurement
1
1
1
83.3
erythrocyte count
1
1
1
65.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
4
91.9
mean reticulocyte volume
3
90.8
mean corpuscular hemoglobin concentration
1
85.2
red blood cell density measurement
1
83.3
erythrocyte count
1
65.4
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
E2F transcription factor 8
VGNC:1052
451072
Macaque
E2F transcription factor 8
702368
Mouse
MGI:1922038
108961
Rat
RGD:1308091
308607
Dog
E2F transcription factor 8
VGNC:40170
476885
Species
Name
OMA
EggNOG
Inparanoid
Chimp
E2F transcription factor 8
Macaque
E2F transcription factor 8
Mouse
Rat
Dog
E2F transcription factor 8
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-A0AVK6-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (8)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
RNA Polymerase II Transcription
Reactome
TP53 Regulates Transcription of Cell Cycle Genes
Reactome
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Generic Transcription Pathway
RNA Polymerase II Transcription
TP53 Regulates Transcription of Cell Cycle Genes
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest
Gene Ontology Terms (28)
Items per page:
10
1 – 10 of 10
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (140)
1 – 10 of 140
TTC33
Tdark
Novelty:  0.31237949
p_int:  0.873809531
p_ni:  0.123440559
p_wrong:  0.00274991
Score:  0.54
Data Source:  BioPlex,STRINGDB
TP53
Tchem
Family:  TF
Novelty:  0.00001907
Score:  0.974
Data Source:  STRINGDB
E2F7
Tbio
Family:  TF
Novelty:  0.00797578
Score:  0.958
Data Source:  Reactome,STRINGDB
E2F1
Tbio
Family:  TF
Novelty:  0.00277137
Score:  0.954
Data Source:  STRINGDB
CCNA2
Tchem
Novelty:  0.00049887
Score:  0.944
Data Source:  STRINGDB
RRM2
Tclin
Family:  Enzyme
Novelty:  0.00112948
Score:  0.934
Data Source:  STRINGDB
BUB1B
Tbio
Family:  Kinase
Novelty:  0.00239073
Score:  0.933
Data Source:  STRINGDB
CDCA8
Tbio
Novelty:  0.01448513
Score:  0.932
Data Source:  STRINGDB
DLGAP5
Tbio
Novelty:  0.01673312
Score:  0.928
Data Source:  STRINGDB
TOP2A
Tclin
Family:  Enzyme
Novelty:  0.00122788
Score:  0.927
Data Source:  STRINGDB
Publication Statistics
PubMed Score  86.88

PubMed score by year
PubTator Score  20.37

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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