Tbio TMEM129 E3 ubiquitin-protein ligase TM129

Protein Summary

Description

E3 ubiquitin-protein ligase involved in ER-associated protein degradation, preferentially associates with the E2 enzyme UBE2J2. Exploited by viral US11 proteins to mediate HLA class I proteins degradation.

Uniprot Accession IDs

• A0AVI4
• A6NH49
• A6NI98
• D3DVP8

Gene Name

• TMEM129

Ensembl ID

• ENST00000303277
• ENSP00000305243
• ENSG00000168936
• ENST00000382936
• ENSP00000372394
• ENST00000536901
• ENSP00000441812

Symbol

• D4S2561E

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.74
cell type or tissue	0.65
histone modification site profile	0.64
disease perturbation	0.62
tissue sample	0.62

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.41   (req: < 5)

Gene RIFs: 6   (req: <= 3)

Antibodies: 2   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.41   (req: >= 5)

Gene RIFs: 6   (req: > 3)

Antibodies: 2   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0