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Tbio
TMEM129
E3 ubiquitin-protein ligase TM129

Protein Summary
Description
E3 ubiquitin-protein ligase involved in ER-associated protein degradation, preferentially associates with the E2 enzyme UBE2J2. Exploited by viral US11 proteins to mediate HLA class I proteins degradation.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000303277
  • ENSP00000305243
  • ENSG00000168936
  • ENST00000382936
  • ENSP00000372394
  • ENST00000536901
  • ENSP00000441812

Symbol
  • D4S2561E
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.74
cell type or tissue
0.65
histone modification site profile
0.64
disease perturbation
0.62
tissue sample
0.62


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.23   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 2   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.23   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 2   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (61)
UBE2J2
Tbio
Novelty:  0.2367348
Score:  0.97
Data Source:  STRINGDB
DERL1
Tbio
Novelty:  0.01382722
Score:  0.965
Data Source:  STRINGDB
VCP
Tchem
Family:  Enzyme
Novelty:  0.00103317
Score:  0.94
Data Source:  STRINGDB
SELENOS
Tbio
Novelty:  0.01108715
Score:  0.934
Data Source:  STRINGDB
UBA52
Tbio
Novelty:  0.01637744
Score:  0.9
Data Source:  STRINGDB
RPS27A
Tbio
Novelty:  0.00658124
Score:  0.9
Data Source:  STRINGDB
UBB
Tbio
Novelty:  0.00661254
Score:  0.9
Data Source:  STRINGDB
UBC
Tbio
Novelty:  0.00204643
Score:  0.9
Data Source:  STRINGDB
SLBP
Tbio
Novelty:  0.00685735
Score:  0.783
Data Source:  STRINGDB
DERL2
Tbio
Novelty:  0.02479307
Score:  0.703
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
E3 ubiquitin ligases ubiquitinate target proteins (R-HSA-8866654)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
E3 ubiquitin ligases ubiquitinate target proteins
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Reactome
Protein ubiquitination
Name
Explore in Pharos
Explore in Source
E3 ubiquitin ligases ubiquitinate target proteins
Metabolism of proteins
Post-translational protein modification
Protein ubiquitination
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted hip circumference
3
9
9
90.7
6
3
3
1.1
88.6
4
2
0
1.2
79.3
serum gamma-glutamyl transferase measurement
1
1
1
64.9
mean reticulocyte volume
1
1
1
63.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted hip circumference
9
90.7
3
1.1
88.6
0
1.2
79.3
serum gamma-glutamyl transferase measurement
1
64.9
mean reticulocyte volume
1
63.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
transmembrane protein 129
VGNC:2959
461065
Mouse
MGI:1915616
68366
Rat
RGD:1310828
305458
Dog
transmembrane protein 129
VGNC:47463
608955
Horse
transmembrane protein 129
VGNC:24192
100052572
Species
Name
OMA
EggNOG
Inparanoid
Chimp
transmembrane protein 129
Mouse
Rat
Dog
transmembrane protein 129
Horse
transmembrane protein 129
Publication Statistics
PubMed Score 2.23
PubMed score by year
PubTator Score 1.89
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title