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Tbio
TTC26
Intraflagellar transport protein 56

Protein Summary
Description
Component of the intraflagellar transport (IFT) complex B required for transport of proteins in the motile cilium. Required for transport of specific ciliary cargo proteins related to motility, while it is neither required for IFT complex B assembly or motion nor for cilium assembly. Required for efficient coupling between the accumulation of GLI2 and GLI3 at the ciliary tips and their dissociation from the negative regulator SUFU. Plays a key role in maintaining the integrity of the IFT complex B and the proper ciliary localization of the IFT complex B components. Not required for IFT complex A ciliary localization or function. Essential for maintaining proper microtubule organization within the ciliary axoneme.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000343187
  • ENSP00000339135
  • ENSG00000105948
  • ENST00000430935
  • ENSP00000410655
  • ENST00000464848
  • ENSP00000419279

Symbol
  • IFT56
  • DYF13
  • IFT56
  • dyf-13
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.88
transcription factor binding site profile
0.72
virus perturbation
0.72
cellular component
0.67
cell type or tissue
0.62


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.91   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 90   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.91   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 90   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (104)
1 – 10 of 104
IFT22
Tbio
Family:  Enzyme
Novelty:  0.18342877
p_int:  0.999688443
p_ni:  0.000311557
Score:  0.988
Data Source:  BioPlex,STRINGDB
IFT27
Tbio
Family:  Enzyme
Novelty:  0.05592902
p_int:  0.999477969
p_ni:  0.000522031
Score:  0.978
Data Source:  BioPlex,STRINGDB
TTC30A
Tdark
Novelty:  1.41742212
p_int:  0.999266831
p_ni:  0.000733169
Score:  0.995
Data Source:  BioPlex,STRINGDB
TTC30B
Tbio
Novelty:  0.10944566
p_int:  0.999154142
p_ni:  0.000845858
Score:  0.996
Data Source:  BioPlex,STRINGDB
HK3
Tbio
Family:  Kinase
Novelty:  0.0151241
p_int:  0.998798256
p_ni:  0.001201744
Score:  0.513
Data Source:  BioPlex,STRINGDB
ABTB2
Tdark
Novelty:  0.45729157
p_int:  0.814031148
p_ni:  0.185968852
Data Source:  BioPlex
IFT57
Tbio
Novelty:  0.03373199
p_int:  0.786704252
p_ni:  0.213295748
Score:  0.996
Data Source:  BioPlex,STRINGDB
IFT88
Tbio
Novelty:  0.00727114
Score:  0.994
Data Source:  STRINGDB
IFT46
Tdark
Novelty:  0.11310911
Score:  0.993
Data Source:  STRINGDB
IFT81
Tbio
Novelty:  0.01610195
Score:  0.993
Data Source:  STRINGDB
Pathways (5)
Cilium Assembly (R-HSA-5617833)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cilium Assembly
Reactome
Intraflagellar transport
Reactome
Organelle biogenesis and maintenance
Name
Explore in Pharos
Explore in Source
Cilium Assembly
Intraflagellar transport
Organelle biogenesis and maintenance
Gene Ontology Terms (16)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
2
2
2
74
lymphocyte count
2
1
2
72.9
platelet crit
1
1
1
71
eosinophil percentage of leukocytes
1
1
1
67.4
reticulocyte measurement
3
3
3
66.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
2
74
lymphocyte count
2
72.9
platelet crit
1
71
eosinophil percentage of leukocytes
1
67.4
reticulocyte measurement
3
66.5
Find similar targets by:
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
tetratricopeptide repeat domain 26
VGNC:4552
472530
Macaque
tetratricopeptide repeat domain 26
715688
Mouse
MGI:2444853
264134
Rat
RGD:1561363
500086
Dog
tetratricopeptide repeat domain 26
VGNC:47947
100856352
Species
Name
OMA
EggNOG
Inparanoid
Chimp
tetratricopeptide repeat domain 26
Macaque
tetratricopeptide repeat domain 26
Mouse
Rat
Dog
tetratricopeptide repeat domain 26
Publication Statistics
PubMed Score 11.91
PubMed score by year
PubTator Score 3.58
PubTator score by year