TTC26
Intraflagellar transport protein 56
Protein Summary
Component of the intraflagellar transport (IFT) complex B required for transport of proteins in the motile cilium. Required for transport of specific ciliary cargo proteins related to motility, while it is neither required for IFT complex B assembly or motion nor for cilium assembly. Required for efficient coupling between the accumulation of GLI2 and GLI3 at the ciliary tips and their dissociation from the negative regulator SUFU. Plays a key role in maintaining the integrity of the IFT complex B and the proper ciliary localization of the IFT complex B components. Not required for IFT complex A ciliary localization or function. Essential for maintaining proper microtubule organization within the ciliary axoneme.
- ENST00000343187
- ENSP00000339135
- ENSG00000105948
- ENST00000430935
- ENSP00000410655
- ENST00000464848
- ENSP00000419279
- IFT56
- DYF13
- IFT56
- dyf-13
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
histone modification site profile | 0.88 | ||
transcription factor binding site profile | 0.72 | ||
virus perturbation | 0.72 | ||
cellular component | 0.67 | ||
cell type or tissue | 0.62 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 11.91 (req: < 5)
Gene RIFs: 3 (req: <= 3)
Antibodies: 90 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 11.91 (req: >= 5)
Gene RIFs: 3 (req: > 3)
Antibodies: 90 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 9
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (104)
IFT22
Family: Enzyme
Novelty: 0.18342877
p_int: 0.999688443
p_ni: 0.000311557
Score: 0.988
Data Source: BioPlex,STRINGDB
IFT27
Family: Enzyme
Novelty: 0.05592902
p_int: 0.999477969
p_ni: 0.000522031
Score: 0.978
Data Source: BioPlex,STRINGDB
TTC30A
Novelty: 1.41742212
p_int: 0.999266831
p_ni: 0.000733169
Score: 0.995
Data Source: BioPlex,STRINGDB
TTC30B
Novelty: 0.10944566
p_int: 0.999154142
p_ni: 0.000845858
Score: 0.996
Data Source: BioPlex,STRINGDB
HK3
Family: Kinase
Novelty: 0.0151241
p_int: 0.998798256
p_ni: 0.001201744
Score: 0.513
Data Source: BioPlex,STRINGDB
IFT57
Novelty: 0.03373199
p_int: 0.786704252
p_ni: 0.213295748
Score: 0.996
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (5)
Reactome (3)
WikiPathways (2)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Cilium Assembly | ||||
Reactome | Intraflagellar transport | ||||
Reactome | Organelle biogenesis and maintenance | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Cilium Assembly | ||||
Intraflagellar transport | ||||
Organelle biogenesis and maintenance | ||||
Viral Interactions (0)
Gene Ontology Terms (16)
Functions (1)
Components (7)
Processes (8)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Disease Associations (null)
GWAS Traits (13)
Items per page:
1 – 5 of 13
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
eosinophil count | 2 | 2 | 2 | 74 | |||||
lymphocyte count | 2 | 1 | 2 | 72.9 | |||||
platelet crit | 1 | 1 | 1 | 71 | |||||
eosinophil percentage of leukocytes | 1 | 1 | 1 | 67.4 | |||||
reticulocyte measurement | 3 | 3 | 3 | 66.5 | |||||
Items per page:
1 – 5 of 13
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
eosinophil count | 2 | 74 | |||||
lymphocyte count | 2 | 72.9 | |||||
platelet crit | 1 | 71 | |||||
eosinophil percentage of leukocytes | 1 | 67.4 | |||||
reticulocyte measurement | 3 | 66.5 | |||||
Find similar targets by:
IDG Resources
Orthologs (16)
1 – 5 of 16
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | tetratricopeptide repeat domain 26 | VGNC:4552 | 472530 | |||||
Macaque | tetratricopeptide repeat domain 26 | 715688 | ||||||
Mouse | MGI:2444853 | 264134 | ||||||
Rat | RGD:1561363 | 500086 | ||||||
Dog | tetratricopeptide repeat domain 26 | VGNC:47947 | 100856352 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | tetratricopeptide repeat domain 26 | |||||
Macaque | tetratricopeptide repeat domain 26 | |||||
Mouse | ||||||
Rat | ||||||
Dog | tetratricopeptide repeat domain 26 | |||||
Publication Statistics
PubMed Score 11.91
PubMed score by year
PubTator Score 3.58
PubTator score by year
Related Publications
Text Mined References (9)
GeneRif Annotations (3)
Items per page:
0 of 0
PMID | Year | Title |
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