Tbio SLC12A8 Solute carrier family 12 member 8

Protein Summary

Description

Cation/chloride cotransporter that may play a role in the control of keratinocyte proliferation. This gene is thought to be a candidate for psoriasis susceptibility. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Sep 2010]

Uniprot Accession IDs

• A0AV02
• C9JJJ2
• Q68D04
• Q6I9Z2
• Q6P4C0
• Q7Z3A6
• Q86WK0
• Q8NFX9
• Q8WUI3
• Q96RF9
• Q9H5P9

Gene Name

• SLC12A8

Ensembl ID

• ENST00000393469
• ENSP00000377112
• ENSG00000221955
• ENST00000430155
• ENSP00000415713
• ENST00000469902
• ENSP00000418783

Symbol

• CCC9
• CCC9

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.85
transcription factor	0.73
histone modification site profile	0.72
PubMedID	0.71
transcription factor perturbation	0.61

Protein Classes

DTO Classes

Protein / Transporter / Slc Superfamily Of Solute Carriers / Slc12 Family Of Cation-coupled Chloride Transporters / Solute Carrier Family 12 Member 8

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.96   (req: < 5)

Gene RIFs: 8   (req: <= 3)

Antibodies: 36   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.96   (req: >= 5)

Gene RIFs: 8   (req: > 3)

Antibodies: 36   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0