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Tdark
LCE6A
Late cornified envelope protein 6A

Protein Summary
Description
Precursors of the cornified envelope of the stratum corneum.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000431011
  • ENSP00000411070
  • ENSG00000235942

Symbol
  • C1orf44
  • C1orf44
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue
0.48
cell line
0.42
transcription factor
0.34
biological term
0.33
microRNA
0.21


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.82   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 14   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.82   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 14   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (44)
LCE2D
Tdark
Novelty:  1.74927
Score:  0.978
Data Source:  STRINGDB
LCE1A
Tbio
Novelty:  0.04596696
Score:  0.976
Data Source:  STRINGDB
LCE1B
Tbio
Novelty:  0.06933554
Score:  0.973
Data Source:  STRINGDB
LCE5A
Tdark
Novelty:  0.94159494
Score:  0.96
Data Source:  STRINGDB
LCE1E
Tdark
Novelty:  0.46343337
Score:  0.959
Data Source:  STRINGDB
SPRR2B
Tdark
Novelty:  0.36342019
Score:  0.957
Data Source:  STRINGDB
LCE2C
Tdark
Novelty:  4.51851552
Score:  0.95
Data Source:  STRINGDB
LCE2B
Tdark
Novelty:  0.88335558
Score:  0.95
Data Source:  STRINGDB
SPRR2F
Tdark
Novelty:  0.35614731
Score:  0.948
Data Source:  STRINGDB
LCE3C
Tbio
Novelty:  0.04910233
Score:  0.947
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Developmental Biology (R-HSA-1266738)

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Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Developmental Biology
Reactome
Formation of the cornified envelope
Reactome
Keratinization
Name
Explore in Pharos
Explore in Source
Developmental Biology
Formation of the cornified envelope
Keratinization
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (1)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
asthma
2
2
0
1.1
78.5
vitamin D measurement
1
2
2
51.2
1
1
0
1.2
43.6
1
1
0
1.2
37.4
leukocyte count
1
1
1
21.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
asthma
0
1.1
78.5
vitamin D measurement
2
51.2
0
1.2
43.6
0
1.2
37.4
leukocyte count
1
21.6
IDG Resources
No IDG generated resources found
Orthologs (2)
1 – 2 of 2
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
late cornified envelope 6A
VGNC:10706
100611017
Mouse
MGI:1925632
78382
Species
Name
OMA
EggNOG
Inparanoid
Chimp
late cornified envelope 6A
Mouse
Publication Statistics
PubMed Score 0.82
PubMed score by year
PubTator Score 0.05
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title