Pharos : Ligand Details

Target Activities

Explore Associated and Predicted Targets

DRD2

Tclin

D(2) dopamine receptor

17 Activities

Items per page:

1 – 10 of 17

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
Ki	8.55		9430133

Ki	9.1	Eur J Med Chem, (2018) 145:None:790	29407591

Ki	9.07	Eur J Med Chem, (2019) 179:None:1	31229883

Ki	9.05	Eur J Med Chem, (2019) 179:None:1	31229883

Ki	9.05	Eur J Med Chem, (2019) 170:None:261	30904783

Ki	8.68	ACS Med Chem Lett, (2017) 8:4:390	28435524

Ki	8.68	Eur J Med Chem, (2020) 185:None:111857	31734022

Ki	8.55	J. Med. Chem., (2001) 44:4:477	11170639

Ki	8.51	Bioorg. Med. Chem., (2008) 16:15:7291	18595716

Ki	8.32	J. Med. Chem., (2013) 56:22:8955	23919353

HTR2A

Tclin

5-hydroxytryptamine receptor 2A

10 Activities

Items per page:

1 – 10 of 10

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Ki	10.1		Bioorg. Med. Chem. Lett., (2008) 18:2:489	18160289

Ki	9.6		J. Med. Chem., (2001) 44:4:477	11170639

Ki	9.55		None, (2013) None:None:None

Ki	9.52		J. Med. Chem., (2004) 47:6:1303	14998318

Ki	9.41		Bioorg. Med. Chem., (2008) 16:15:7291	18595716

Ki	9.4		J. Med. Chem., (2013) 56:22:8955	23919353

IC50	9.38		J. Med. Chem., (2005) 48:21:6523	16220969

Ki	9.2		J. Med. Chem., (2007) 50:21:5103	17880057

Ki	8.77		Eur J Med Chem, (2018) 145:None:790	29407591

Ki	9.4	ANTAGONIST	https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL708

KCNH2

Tclin

Potassium voltage-gated channel subfamily H member 2

9 Activities

Items per page:

1 – 9 of 9

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
IC50	6.92	Bioorg. Med. Chem. Lett., (2003) 13:16:2773	12873512

IC50	6.92	Bioorg. Med. Chem. Lett., (2005) 15:11:2886	15911273

IC50	6.92	Bioorg. Med. Chem., (2008) 16:11:6252	18448342

IC50	6.9	J. Med. Chem., (2009) 52:14:4266	19534531

IC50	6.9	J. Med. Chem., (2009) 52:14:4266	19534531

IC50	6.9	Eur. J. Med. Chem., (2011) 46:2:618	21185626

IC50	6.82	J. Med. Chem., (2002) 45:18:3844	12190308

IC50	6.82	Bioorg. Med. Chem. Lett., (2005) 15:6:1737	15745831

IC50	6.82	Eur. J. Med. Chem., (2009) 44:5:1926	19110341

HTR2C

Tclin

5-hydroxytryptamine receptor 2C

7 Activities

Items per page:

1 – 7 of 7

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
Ki	9.26	J. Med. Chem., (2001) 44:4:477	11170639

Ki	9.14	Bioorg. Med. Chem., (2008) 16:15:7291	18595716

Ki	8.9	J. Med. Chem., (2007) 50:21:5103	17880057

Ki	8.89	J. Med. Chem., (2013) 56:22:8955	23919353

Ki	8	None, (2013) None:None:None

Ki	7.89	J. Med. Chem., (2004) 47:6:1303	14998318

Ki	7.89	Bioorg. Med. Chem. Lett., (2010) 20:18:5431	20719507

DRD3

Tclin

D(3) dopamine receptor

5 Activities

Items per page:

1 – 5 of 5

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
Ki	8.2	J. Med. Chem., (2007) 50:21:5103	17880057

Ki	8.14	Bioorg. Med. Chem., (2008) 16:15:7291	18595716

Ki	8.14	J. Med. Chem., (2013) 56:22:8955	23919353

Ki	8.12	J. Med. Chem., (2004) 47:6:1303	14998318

Ki	8	J. Med. Chem., (2001) 44:4:477	11170639

HTR1A

Tclin

5-hydroxytryptamine receptor 1A

5 Activities

Items per page:

1 – 5 of 5

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
Ki	8.8	J. Med. Chem., (2007) 50:21:5103	17880057

Ki	8.7	Eur J Med Chem, (2018) 145:None:790	29407591

Ki	8.6	Bioorg. Med. Chem., (2008) 16:15:7291	18595716

Ki	8.4	Bioorg. Med. Chem. Lett., (2008) 18:2:489	18160289

Ki	7.43	J. Med. Chem., (2001) 44:4:477	11170639

HTR6

Tchem

5-hydroxytryptamine receptor 6

5 Activities

Items per page:

1 – 5 of 5

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
Ki	7.7	Eur J Med Chem, (2018) 145:None:790	29407591

Ki	7.21	Bioorg. Med. Chem. Lett., (2010) 20:18:5431	20719507

Ki	7.21	J. Med. Chem., (2013) 56:22:8955	23919353

Ki	7.2	J. Med. Chem., (2007) 50:21:5103	17880057

Ki	7.12	Bioorg. Med. Chem., (2008) 16:15:7291	18595716

HTR7

Tclin

5-hydroxytryptamine receptor 7

4 Activities

Items per page:

1 – 4 of 4

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
	8.4		15821958

Ki	8.3	J. Med. Chem., (2007) 50:21:5103	17880057

Ki	8.3	Eur J Med Chem, (2018) 145:None:790	29407591

Ki	8.22	J. Med. Chem., (2013) 56:22:8955	23919353

SLC6A4

Tclin

Sodium-dependent serotonin transporter

4 Activities

Items per page:

1 – 4 of 4

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
Ki	7.28

Ki	7.28	Bioorg. Med. Chem., (2008) 16:15:7291	18595716

Ki	7.1	J. Med. Chem., (2007) 50:21:5103	17880057

Ki	6.95	None, (2013) None:None:None

DRD4

Tchem

D(4) dopamine receptor

4 Activities

Items per page:

1 – 4 of 4

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
Ki	7.5	Bioorg. Med. Chem., (2008) 16:15:7291	18595716

Ki	7.41	J. Med. Chem., (2004) 47:6:1303	14998318

Ki	7.41	J. Med. Chem., (2001) 44:4:477	11170639

Ki	7.3	J. Med. Chem., (2007) 50:21:5103	17880057

HRH1

Tclin

Histamine H1 receptor

2 Activities

Items per page:

1 – 2 of 2

Activity Type	Activity Value -log(M)	Activity Reference	Publications (PubMed IDs)
Ki	8.28	J. Med. Chem., (2004) 47:6:1303	14998318

Ki	7.33	Bioorg. Med. Chem., (2008) 16:15:7291	18595716

H1F0

Tchem

Histone H1.0

2 Activities

Items per page:

1 – 2 of 2

Activity Type	Activity Value -log(M)	Activity Reference
Ki	7.82	None, (2013) None:None:None

Ki	7.82	https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL708

HTR1B

Tclin

5-hydroxytryptamine receptor 1B

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
	8.3			8935801

HTR1D

Tclin

5-hydroxytryptamine receptor 1D

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
	9			8935801

HTR1E

Tchem

5-hydroxytryptamine receptor 1E

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
	6.4			8935801

SLC6A2

Tclin

Sodium-dependent noradrenaline transporter

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Ki	7.32			18595716

HTR2B

Tclin

5-hydroxytryptamine receptor 2B

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Ki	8.8		J. Med. Chem., (2007) 50:21:5103	17880057

ADRA1A

Tclin

Alpha-1A adrenergic receptor

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Ki	8.22		None, (2013) None:None:None

DRD1

Tclin

D(1A) dopamine receptor

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
Ki	8.02		J. Med. Chem., (2001) 44:4:477	11170639