ziprasidone
a benzisothiazoylpiperazine derivative; has combined dopamine and serotonin receptor antagonist activity; structurally related to tiospirone
Ligand Summary
UNII: 6UKA5VEJ6X
PubChem: 60854
PubChem: 219099
Guide to Pharmacology: 59
ChEMBL: CHEMBL708
ChEMBL: CHEMBL1712
DrugCentral: 2865
LyCHI: 4P3RKTZ5ANZ8
Target Activities
DRD2
D(2) dopamine receptor
12 Activities
Items per page:
1 – 10 of 12
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Ki | 7.9 | J. Med. Chem., (2007) 50:21:5103 | ||||
Ki | 8.01 | J. Med. Chem., (2004) 47:6:1303 | ||||
Ki | 8.07 | J. Med. Chem., (2012) 55:22:9735 | ||||
Ki | 8.3 | Bioorg. Med. Chem. Lett., (2008) 18:2:489 | ||||
Ki | 8.3 | None, (2013) None:None:None | ||||
Ki | 8.3 | None, (2013) None:None:None | ||||
IC50 | 8.3 | J. Med. Chem., (2005) 48:21:6523 | ||||
Ki | 8.32 | J. Med. Chem., (2013) 56:22:8955 | ||||
Ki | 8.51 | Bioorg. Med. Chem., (2008) 16:15:7291 | ||||
Ki | 8.55 | J. Med. Chem., (2001) 44:4:477 | ||||
HTR2A
5-hydroxytryptamine receptor 2A
10 Activities
Items per page:
1 – 10 of 10
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Ki | 9.2 | J. Med. Chem., (2007) 50:21:5103 | ||||
IC50 | 9.38 | J. Med. Chem., (2005) 48:21:6523 | ||||
Ki | 9.4 | J. Med. Chem., (2013) 56:22:8955 | ||||
Ki | 9.41 | Bioorg. Med. Chem., (2008) 16:15:7291 | ||||
Ki | 9.52 | J. Med. Chem., (2004) 47:6:1303 | ||||
Ki | 9.55 | None, (2013) None:None:None | ||||
Ki | 9.55 | None, (2013) None:None:None | ||||
Ki | 9.6 | J. Med. Chem., (2001) 44:4:477 | ||||
Ki | 10.1 | Bioorg. Med. Chem. Lett., (2008) 18:2:489 | ||||
Ki | 9.4 | ANTAGONIST | ||||
HTR2C
5-hydroxytryptamine receptor 2C
8 Activities
Items per page:
1 – 8 of 8
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Ki | 7.89 | J. Med. Chem., (2004) 47:6:1303 | ||||
Ki | 7.89 | Bioorg. Med. Chem. Lett., (2010) 20:18:5431 | ||||
Ki | 8 | None, (2013) None:None:None | ||||
Ki | 8 | None, (2013) None:None:None | ||||
Ki | 8.89 | J. Med. Chem., (2013) 56:22:8955 | ||||
Ki | 8.9 | J. Med. Chem., (2007) 50:21:5103 | ||||
Ki | 9.14 | Bioorg. Med. Chem., (2008) 16:15:7291 | ||||
Ki | 9.26 | J. Med. Chem., (2001) 44:4:477 | ||||
KCNH2
Potassium voltage-gated channel subfamily H member 2
7 Activities
Items per page:
1 – 7 of 7
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 6.82 | Eur. J. Med. Chem., (2009) 44:5:1926 | ||||
IC50 | 6.9 | Eur. J. Med. Chem., (2011) 46:2:618 | ||||
IC50 | 6.9 | J. Med. Chem., (2009) 52:14:4266 | ||||
IC50 | 6.9 | J. Med. Chem., (2009) 52:14:4266 | ||||
IC50 | 6.92 | Bioorg. Med. Chem. Lett., (2003) 13:16:2773 | ||||
IC50 | 6.92 | Bioorg. Med. Chem., (2008) 16:11:6252 | ||||
IC50 | 6.92 | Bioorg. Med. Chem. Lett., (2005) 15:11:2886 | ||||
SLC6A4
Sodium-dependent serotonin transporter
5 Activities
Items per page:
1 – 5 of 5
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Ki | 6.95 | None, (2013) None:None:None | ||||
Ki | 6.95 | None, (2013) None:None:None | ||||
Ki | 7.1 | J. Med. Chem., (2007) 50:21:5103 | ||||
Ki | 7.28 | Bioorg. Med. Chem., (2008) 16:15:7291 | ||||
Ki | 7.28000021 | |||||
DRD3
D(3) dopamine receptor
5 Activities
Items per page:
1 – 5 of 5
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Ki | 8 | J. Med. Chem., (2001) 44:4:477 | ||||
Ki | 8.12 | J. Med. Chem., (2004) 47:6:1303 | ||||
Ki | 8.14 | Bioorg. Med. Chem., (2008) 16:15:7291 | ||||
Ki | 8.14 | J. Med. Chem., (2013) 56:22:8955 | ||||
Ki | 8.2 | J. Med. Chem., (2007) 50:21:5103 | ||||
HTR6
5-hydroxytryptamine receptor 6
4 Activities
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1 – 4 of 4
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Ki | 7.12 | Bioorg. Med. Chem., (2008) 16:15:7291 | ||||
Ki | 7.2 | J. Med. Chem., (2007) 50:21:5103 | ||||
Ki | 7.21 | Bioorg. Med. Chem. Lett., (2010) 20:18:5431 | ||||
Ki | 7.21 | J. Med. Chem., (2013) 56:22:8955 | ||||
HTR1A
5-hydroxytryptamine receptor 1A
4 Activities
Items per page:
1 – 4 of 4
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Ki | 7.43 | J. Med. Chem., (2001) 44:4:477 | ||||
Ki | 8.4 | Bioorg. Med. Chem. Lett., (2008) 18:2:489 | ||||
Ki | 8.6 | Bioorg. Med. Chem., (2008) 16:15:7291 | ||||
Ki | 8.8 | J. Med. Chem., (2007) 50:21:5103 | ||||
DRD4
D(4) dopamine receptor
4 Activities
Items per page:
1 – 4 of 4
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Ki | 7.3 | J. Med. Chem., (2007) 50:21:5103 | ||||
Ki | 7.41 | J. Med. Chem., (2004) 47:6:1303 | ||||
Ki | 7.41 | J. Med. Chem., (2001) 44:4:477 | ||||
Ki | 7.5 | Bioorg. Med. Chem., (2008) 16:15:7291 | ||||
HTR7
5-hydroxytryptamine receptor 7
3 Activities
ADRA1A
Alpha-1A adrenergic receptor
2 Activities
Items per page:
1 – 2 of 2
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Ki | 8.22 | None, (2013) None:None:None | ||||
Ki | 8.22 | None, (2013) None:None:None | ||||
H1F0
Histone H1.0
2 Activities
Items per page:
1 – 2 of 2
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Ki | 7.82 | None, (2013) None:None:None | ||||
Ki | 7.82 | None, (2013) None:None:None | ||||
HRH1
Histamine H1 receptor
2 Activities
DRD1
D(1A) dopamine receptor
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Ki | 8.02 | J. Med. Chem., (2001) 44:4:477 | ||||
HTR2B
5-hydroxytryptamine receptor 2B
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Ki | 8.8 | J. Med. Chem., (2007) 50:21:5103 | ||||
HTR1B
5-hydroxytryptamine receptor 1B
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
8.3 | ||||||
HTR1D
5-hydroxytryptamine receptor 1D
1 Activities
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1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
9 | ||||||
HTR1E
5-hydroxytryptamine receptor 1E
1 Activities
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1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
6.4 | ||||||
SLC6A2
Sodium-dependent noradrenaline transporter
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Ki | 7.32000017 | |||||