zileuton
an orally active inhibitor of 5-lipoxygenase, the enzyme that catalyzes the formation of leukotrienes from arachidonic acid
Ligand Summary
UNII: V1L22WVE2S
PubChem: 60490
Guide to Pharmacology: 5297
ChEMBL: CHEMBL93
DrugCentral: 2862
LyCHI: 96L5WFP1BGGT
Target Activities
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10
1 – 3 of 3
ALOX5
Arachidonate 5-lipoxygenase
35 Activities
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1 – 10 of 35
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 6 | J. Nat. Prod., (2014) 77:3:441 | ||||
IC50 | 6 | Eur J Med Chem, (2016) 124:None:428 | ||||
IC50 | 6.04 | Eur. J. Med. Chem., (2016) 113:None:1 | ||||
IC50 | 6.05 | J. Med. Chem., (2013) 56:22:9031 | ||||
IC50 | 6.05 | J. Med. Chem., (2009) 52:11:3474 | ||||
IC50 | 6.05 | Eur. J. Med. Chem., (2015) 94:None:132 | ||||
IC50 | 6.06 | Bioorg. Med. Chem. Lett., (2004) 14:9:2265 | ||||
IC50 | 6.06 | Bioorg. Med. Chem. Lett., (2004) 14:22:5591 | ||||
IC50 | 6.1 | Bioorg. Med. Chem., (2010) 18:11:3910 | ||||
IC50 | 6.1 | Eur. J. Med. Chem., (2011) 46:10:5021 | ||||
EPHX2
Bifunctional epoxide hydrolase 2
2 Activities
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1 – 2 of 2
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 6.23 | J. Med. Chem., (2013) 56:4:1777 | ||||
IC50 | 6.23 | |||||
ALOX5AP
Arachidonate 5-lipoxygenase-activating protein
1 Activities
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1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 6.24 | Eur. J. Med. Chem., (2016) 113:None:1 | ||||