Pharos : Ligand Details - zileuton

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Ligand Summary

Ligand Structure

Rendered image for the query structure

Description

an orally active inhibitor of 5-lipoxygenase, the enzyme that catalyzes the formation of leukotrienes from arachidonic acid

Synonyms & Links

UNII: V1L22WVE2S

PubChem: 60490

Guide to Pharmacology: 5297

ChEMBL: CHEMBL93

DrugCentral: 2862

LyCHI: 96L5WFP1BGGT

Target Activities

Explore Associated and Predicted Targets

ALOX5

Tclin

Arachidonate 5-lipoxygenase

48 Activities

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1 – 10 of 48

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	6.52			24508141

IC50	5.82			30199704

IC50	6.4			1848634

IC50	7		J Nat Prod, (2019) 82:7:1839	31268709

IC50	6.82		Eur J Med Chem, (2018) 156:None:534	30025348

IC50	6.52		Bioorg. Med. Chem., (2014) 22:5:1642	24508141

IC50	6.5		J. Med. Chem., (2000) 43:4:690	10691695

IC50	6.46		J Nat Prod, (2017) 80:4:999	28322565

IC50	6.4		J. Med. Chem., (2008) 51:24:8068	19053751

IC50	6.39		J. Med. Chem., (2013) 56:20:7997	24074025

EPHX2

Tchem

Bifunctional epoxide hydrolase 2

2 Activities

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1 – 2 of 2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	6.23		J. Med. Chem., (2013) 56:4:1777	23356879

IC50	6.23		https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL93

ALOX15

Tchem

Arachidonate 15-lipoxygenase

2 Activities

Items per page:

1 – 2 of 2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	6.4		Bioorg Med Chem Lett, (2017) 27:8:1649	28318946

IC50	6.4		https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL93

PTGES

Tchem

Prostaglandin E synthase

2 Activities

Items per page:

1 – 2 of 2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	6.22		Eur J Med Chem, (2018) 156:None:815	30053720

IC50	6.22		https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL93

ALOX5AP

Tchem

Arachidonate 5-lipoxygenase-activating protein

1 Activities

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1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	6.24		Eur. J. Med. Chem., (2016) 113:None:1	26922224

LTA4H

Tchem

Leukotriene A-4 hydrolase

1 Activities

Items per page:

1 – 1 of 1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)
IC50	6.07		J. Med. Chem., (2000) 43:4:721	10691697