zileuton
Ligand Summary
an orally active inhibitor of 5-lipoxygenase, the enzyme that catalyzes the formation of leukotrienes from arachidonic acid
UNII: V1L22WVE2S
PubChem: 60490
Guide to Pharmacology: 5297
ChEMBL: CHEMBL93
DrugCentral: 2862
LyCHI: 96L5WFP1BGGT
Target Activities
ALOX5
Arachidonate 5-lipoxygenase
48 Activities
Items per page:
1 – 10 of 48
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
IC50 | 6.52 | |||||
IC50 | 5.82 | |||||
IC50 | 6.4 | |||||
IC50 | 7 | J Nat Prod, (2019) 82:7:1839 | ||||
IC50 | 6.82 | Eur J Med Chem, (2018) 156:None:534 | ||||
IC50 | 6.52 | Bioorg. Med. Chem., (2014) 22:5:1642 | ||||
IC50 | 6.5 | J. Med. Chem., (2000) 43:4:690 | ||||
IC50 | 6.46 | J Nat Prod, (2017) 80:4:999 | ||||
IC50 | 6.4 | J. Med. Chem., (2008) 51:24:8068 | ||||
IC50 | 6.39 | J. Med. Chem., (2013) 56:20:7997 | ||||
EPHX2
Bifunctional epoxide hydrolase 2
2 Activities
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1 – 2 of 2
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
IC50 | 6.23 | J. Med. Chem., (2013) 56:4:1777 | ||||
IC50 | 6.23 | |||||
ALOX15
Arachidonate 15-lipoxygenase
2 Activities
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1 – 2 of 2
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
IC50 | 6.4 | Bioorg Med Chem Lett, (2017) 27:8:1649 | ||||
IC50 | 6.4 | |||||
PTGES
Prostaglandin E synthase
2 Activities
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1 – 2 of 2
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
IC50 | 6.22 | Eur J Med Chem, (2018) 156:None:815 | ||||
IC50 | 6.22 | |||||
ALOX5AP
Arachidonate 5-lipoxygenase-activating protein
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
IC50 | 6.24 | Eur. J. Med. Chem., (2016) 113:None:1 | ||||
LTA4H
Leukotriene A-4 hydrolase
1 Activities
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1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
IC50 | 6.07 | J. Med. Chem., (2000) 43:4:721 | ||||