vigabatrin
Ligand Summary
The precise mechanism of vigabatrin's anti-seizure effect is unknown, but it is believed to be the result of its action as an irreversible inhibitor of gamma-aminobutyric acid transaminase (GABA-T), the enzyme responsible for the metabolism of the inhibitory neurotransmitter GABA. This action results in increased levels of GABA in the central nervous system.
UNII: GR120KRT6K
PubChem: 5665
Guide to Pharmacology: 4821
ChEMBL: CHEMBL89598
DrugCentral: 2819
LyCHI: 12RKXBK1T2AJ
Target Activities
ABAT
4-aminobutyrate aminotransferase, mitochondrial
2 Activities
Items per page:
1 – 2 of 2
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
Ki | 3.07 | |||||
INHIBITOR | ||||||
SLC32A1
Vesicular inhibitory amino acid transporter
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
---|---|---|---|---|---|---|
IC50 | 2.1 | |||||