upadacitinib
Ligand Summary
Upadacitinib is a Janus kinase (JAK) inhibitor. JAKs are intracellular enzymes which transmit signals arising from cytokine or growth factor-receptor interactions on the cellular membrane to influence cellular processes of hematopoiesis and immune cell function. Within the signaling pathway, JAKs phosphorylate and activate Signal Transducers and Activators of Transcription (STATs) which modulate intracellular activity including gene expression. Upadacitinib modulates the signaling pathway at the point of JAKs, preventing the phosphorylation and activation of STATs.
UNII: 4RA0KN46E0
PubChem: 58557659
Guide to Pharmacology: 9246
ChEMBL: CHEMBL3622821
DrugCentral: 5346
LyCHI: F9TLF4UV5U1J
Target Activities
12 Activities
Items per page:
1 – 10 of 12
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