You are using an outdated browser. Please upgrade your browser to improve your experience.

umbralisib

Ligand Summary
Ligand Structure
Rendered image for the query structure
Description
Umbralisib inhibits multiple kinases. In biochemical and cell-based assays, umbralisib inhibited PI3Kdelta and casein kinase CK1-epsilon. PI3K-delta is expressed in normal and malignant B-cells; CK1-epsilon has been implicated in the pathogenesis of cancer cells, including lymphoid malignancies. Umbralisib also inhibited a mutated form of ABL1 in biochemical assays. Umbralisib inhibited cell proliferation, CXCL12-mediated cell adhesion, and CCL19-mediated cell migration in lymphoma cell lines in studies conducted in vitro.
Synonyms & Links
Guide to Pharmacology: 8916
DrugCentral: 5441
LyCHI:  VU4ZSGX14BY3


Target Activities