tucatinib
Ligand Summary
Tucatinib is a tyrosine kinase inhibitor of HER2. In vitro, tucatinib inhibits phosphorylation of HER2 and HER3, resulting in inhibition of downstream MAPK and AKT signaling and cell proliferation, and showed anti-tumor activity in HER2 expressing tumor cells. In vivo, tucatinib inhibited the growth of HER2 expressing tumors. The combination of tucatinib and trastuzumab showed increased anti-tumor activity in vitro and in vivo compared to either drug alone
UNII: 234248D0HH
PubChem: 51039094
ChEMBL: CHEMBL3989868
DrugCentral: 5389
LyCHI: VBWH9LV6H1FT
Target Activities
4 Activities
Items per page:
1 – 4 of 4
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