trifarotene
AKLIEF Cream for topical administration contains 0.005% (50 mcg/g) trifarotene. Trifarotene is a terphenyl acid derivative and is a retinoid. Trifarotene is an agonist of retinoic acid receptors (RAR), with particular activity at the gamma subtype of RAR. Stimulation of RAR results in modulation of target genes which are associated with various processes, including cell differentiation and mediation of inflammation. The exact process by which trifarotene ameliorates acne is unknown.
Ligand Summary
UNII: 0J8RN2W0HK
PubChem: 11518241
Guide to Pharmacology: 9962
ChEMBL: CHEMBL3707313
DrugCentral: 5350
LyCHI: W4BXSF5NLJZG
Target Activities
RARG
Retinoic acid receptor gamma
5 Activities
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1 – 5 of 5
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
EC50 | 8.11 | |||||
Kd | 8.7 | None, (2008) None:None:None | ||||
Kd | 8.7 | |||||
EC50 | 8.11 | Bioorg Med Chem Lett, (2018) 28:10:1736 | ||||
EC50 | 8.11 | AGONIST | ||||
RARB
Retinoic acid receptor beta
3 Activities
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1 – 3 of 3
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
EC50 | 6.9 | |||||
Kd | 7.82 | None, (2008) None:None:None | ||||
Kd | 7.82 | |||||
RARA
Retinoic acid receptor alpha
1 Activities
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1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
EC50 | 6.3 | |||||