triazolam
A short-acting benzodiazepine used in the treatment of insomnia. Some countries temporarily withdrew triazolam from the market because of concerns about adverse reactions, mostly psychological, associated with higher dose ranges. Its use at lower doses with appropriate care and labeling has been reaffirmed by the FDA and most other countries.
Ligand Summary
Target Activities
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10
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GABRA5
Gamma-aminobutyric acid receptor subunit alpha-5
8 Activities
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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Kd | 8.4 | J. Med. Chem., (2008) 51:13:3788 | ||||
Ki | 8.81000042 | |||||
Kd | 8.39999962 | |||||
Ki | 9.02 | POSITIVE ALLOSTERIC MODULATOR | ||||
Ki | 9.2218 | POSITIVE ALLOSTERIC MODULATOR | ||||
Ki | 8.699 | POSITIVE ALLOSTERIC MODULATOR | ||||
Ki | 9.10000038 | POSITIVE ALLOSTERIC MODULATOR | ||||
Ki | 8.699 | POSITIVE ALLOSTERIC MODULATOR | ||||
GABRG2
Gamma-aminobutyric acid receptor subunit gamma-2
8 Activities
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1 – 8 of 8
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Ki | 9.02 | POSITIVE ALLOSTERIC MODULATOR | ||||
Ki | 9.1549 | POSITIVE ALLOSTERIC MODULATOR | ||||
Ki | 9.0969 | POSITIVE ALLOSTERIC MODULATOR | ||||
Ki | 9.2291 | POSITIVE ALLOSTERIC MODULATOR | ||||
Ki | 8.8761 | POSITIVE ALLOSTERIC MODULATOR | ||||
Ki | 8.8447 | POSITIVE ALLOSTERIC MODULATOR | ||||
Ki | 9.2218 | POSITIVE ALLOSTERIC MODULATOR | ||||
Ki | 9.10000038 | POSITIVE ALLOSTERIC MODULATOR | ||||
GABRA1
Gamma-aminobutyric acid receptor subunit alpha-1
7 Activities
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1 – 7 of 7
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Kd | 9 | J. Med. Chem., (2008) 51:13:3788 | ||||
Ki | 9.10000038 | |||||
Kd | 9 | |||||
Ki | 9.1549 | POSITIVE ALLOSTERIC MODULATOR | ||||
Ki | 9.0969 | POSITIVE ALLOSTERIC MODULATOR | ||||
Ki | 8.6383 | POSITIVE ALLOSTERIC MODULATOR | ||||
Ki | 9.10000038 | POSITIVE ALLOSTERIC MODULATOR | ||||
GABRB2
Gamma-aminobutyric acid receptor subunit beta-2
7 Activities
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1 – 7 of 7
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Ki | 9.1549 | POSITIVE ALLOSTERIC MODULATOR | ||||
Ki | 8.8761 | POSITIVE ALLOSTERIC MODULATOR | ||||
Ki | 8.1079 | POSITIVE ALLOSTERIC MODULATOR | ||||
Ki | 8.6383 | POSITIVE ALLOSTERIC MODULATOR | ||||
Ki | 9.2218 | POSITIVE ALLOSTERIC MODULATOR | ||||
Ki | 8.699 | POSITIVE ALLOSTERIC MODULATOR | ||||
Ki | 9.10000038 | POSITIVE ALLOSTERIC MODULATOR | ||||
GABRB3
Gamma-aminobutyric acid receptor subunit beta-3
6 Activities
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1 – 6 of 6
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Ki | 9.02 | POSITIVE ALLOSTERIC MODULATOR | ||||
Ki | 9.0969 | POSITIVE ALLOSTERIC MODULATOR | ||||
Ki | 9.2291 | POSITIVE ALLOSTERIC MODULATOR | ||||
Ki | 8.8447 | POSITIVE ALLOSTERIC MODULATOR | ||||
Ki | 9.10000038 | POSITIVE ALLOSTERIC MODULATOR | ||||
Ki | 8.699 | POSITIVE ALLOSTERIC MODULATOR | ||||
GABRA3
Gamma-aminobutyric acid receptor subunit alpha-3
5 Activities
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1 – 5 of 5
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Ki | 8.84000015 | |||||
Ki | 8.8761 | POSITIVE ALLOSTERIC MODULATOR | ||||
Ki | 8.8447 | POSITIVE ALLOSTERIC MODULATOR | ||||
Ki | 8.1079 | POSITIVE ALLOSTERIC MODULATOR | ||||
Ki | 9.10000038 | POSITIVE ALLOSTERIC MODULATOR | ||||
GABRG3
Gamma-aminobutyric acid receptor subunit gamma-3
5 Activities
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1 – 5 of 5
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Ki | 8.1079 | POSITIVE ALLOSTERIC MODULATOR | ||||
Ki | 8.6383 | POSITIVE ALLOSTERIC MODULATOR | ||||
Ki | 8.699 | POSITIVE ALLOSTERIC MODULATOR | ||||
Ki | 9.10000038 | POSITIVE ALLOSTERIC MODULATOR | ||||
Ki | 8.699 | POSITIVE ALLOSTERIC MODULATOR | ||||
GABRA2
Gamma-aminobutyric acid receptor subunit alpha-2
3 Activities
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1 – 3 of 3
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Ki | 9.22999954 | |||||
Ki | 9.2291 | POSITIVE ALLOSTERIC MODULATOR | ||||
Ki | 9.10000038 | POSITIVE ALLOSTERIC MODULATOR | ||||
GABRD
Gamma-aminobutyric acid receptor subunit delta
1 Activities
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1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Ki | 9.10000038 | POSITIVE ALLOSTERIC MODULATOR | ||||
GABRB1
Gamma-aminobutyric acid receptor subunit beta-1
1 Activities
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1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
Ki | 9.10000038 | POSITIVE ALLOSTERIC MODULATOR | ||||