tranylcypromine
Ligand Summary
A propylamine formed from the cyclization of the side chain of amphetamine. This monoamine oxidase inhibitor is effective in the treatment of major depression, dysthymic disorder, and atypical depression. It also is useful in panic and phobic disorders. (From AMA Drug Evaluations Annual, 1994, p311)
UNII: 3E3V44J4Z9
PubChem: 19493
PubChem: 53628842
ChEMBL: CHEMBL1179
ChEMBL: CHEMBL1255743
DrugCentral: 2715
LyCHI: LM1GZFVJ9TM4
Target Activities
MAOB
Amine oxidase [flavin-containing] B
5 Activities
Items per page:
1 – 5 of 5
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 8.03 | Bioorg Med Chem Lett, (2019) 29:4:544 | ||||
IC50 | 7.46 | J. Med. Chem., (2004) 47:7:1796 | ||||
IC50 | 6.25 | Bioorg Med Chem Lett, (2019) 29:6:844 | ||||
IC50 | 6.22 | None, (2015) None:None:None | ||||
IC50 | 7.48 | INHIBITOR | ||||
CYP2A6
Cytochrome P450 2A6
4 Activities
Items per page:
1 – 4 of 4
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 7.1 | None, None:None:None | ||||
IC50 | 7.1 | |||||
IC50 | 6.01 | None, None:None:None | ||||
IC50 | 6.01 | |||||
MAOA
Amine oxidase [flavin-containing] A
1 Activities
Items per page:
1 – 1 of 1
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
|---|---|---|---|---|---|---|
IC50 | 7.07 | Bioorg Med Chem Lett, (2019) 29:4:544 | ||||