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tolcapone

Ligand Summary
Ligand Structure
Rendered image for the query structure
Description
Tolcapone is a selective and reversible inhibitor of catechol-O-methyltransferase (COMT). The precise mechanism of action of tolcapone is unknown, but it is believed to be related to its ability to inhibit COMT and alter the plasma pharmacokinetics of levodopa. It is believed that these sustained plasma levels of levodopa result in more constant dopaminergic stimulation in the brain, leading to greater effects on the signs and symptoms of Parkinson's disease patients.
Synonyms & Links
Guide to Pharmacology: 6646
DrugCentral: 2697
LyCHI:  DWDDYTUXCFFS


Target Activities