tizanidine
Ligand Summary
Tizanidine is an agonist at alpha2-adrenergic receptor sites and presumably reduces spasticity by increasing presynaptic inhibition of motor neurons. In animal models, tizanidine has no direct effect on skeletal muscle fibers or the neuromuscular junction, and no major effect on monosynaptic spinal reflexes. The effects of tizanidine are greatest on polysynaptic pathways. The overall effect of these actions is thought to reduce facilitation of spinal motor neurons.
UNII: 6AI06C00GW
PubChem: 5487
ChEMBL: CHEMBL1079
DrugCentral: 2683
LyCHI: UVBAZLFK7DQV
Target Activities
7 Activities
Items per page:
1 – 7 of 7
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) | ||
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EC50 | ||||||
EC50 | ||||||
Ki | ||||||
Ki | ||||||
AGONIST | ||||||
EC50 | AGONIST | |||||
EC50 | AGONIST | |||||